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| Efficacy of Kushen Decoction Bath Combined with Black Light in the Treatment of Psoriasis Vulgaris |
| JIANG Hongling, CHEN Xi, et al |
| Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 101100, China |
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Abstract Objective: To observe the efficacy of the Kushen decoction bath combined with black light in the treatment of psoriasis vulgaris. Methods: A simple random grouping method using a random number table was used to divide 102 patients with psoriasis admitted to our hospital from February 2020 to February 2021 into 51 cases each in the observation and control groups. The control group was given black light therapy, while the observation group was treated with a Kushen decoction bath combined with black light therapy. The clinical efficacy of the two groups of patients was compared, and the disease symptoms [Psoriasis Area and Severity Index (PASI), Pruritus Visual Analogue Scale (VAS)], serum-related factors [CC chemokine ligand 20(CCL20), transforming growth factorβ1(TGF-β1), interleukin 17(IL-17), tumor necrosis factor-α(TNF-α)] and levels of T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) were compared before and after treatment. Results: After 2 weeks of treatment, the total clinical efficiency of the observation group (98.53%) was higher than that of the control group (88.24%) (P<0.05). After 2 weeks of treatment, the PASI score, VAS score, and levels of serum-related factors (CCL20, IL-17, TNF-α, TGF-β1) and CD8+ in the two groups were lower than those before treatment, and the differences before and after treatment showed statistical significances between the groups (P<0.05). The levels of CD3+, CD4+, and CD4+/CD8+ in both groups were higher compared to before treatment, and the differences before and after treatment were statistically significant between the groups (P<0.05). Conclusion: Compared with black light irradiation alone, Kushen decoction bath combined with black light irradiation therapy has a more significant efficacy on psoriasis vulgaris, and has a more positive significance in regulating the body’s inflammatory status and immune function, alleviating the immune damage and promoting the skin repair.
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2023, Vol. 29 
