食管癌患者血清NLR LMR NMR与预后的关系研究

doi:10.3969/j.issn.1006-6233.2023.02.014

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Abstract Objective: To analyze the relationship between serum neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), neutrophil-monocyte ratio (NMR), and prognosis in patients with esophageal cancer. Methods: A total of 116 patients with esophageal cancer undergoing radical resection in the hospital were enrolled as an observation group between January 2017 and January 2021, while other 116 healthy controls during the same period were enrolled as the control group. The levels of white blood cell count (WBC), neutrophils, lymphocytes, and monocytes were detected by a hematology analyzer. NLR, LMR, and NMR were analyzed. The 12-month prognosis of patients with esophageal cancer was statistically analyzed. The patients with recurrence increased staging, other organ metastasis, and death was enrolled as a poor prognosis group, while the remaining were enrolled as a good prognosis group. The predictive value of NLR, LMR, and NMR for the prognosis of patients with esophageal cancer was analyzed by receiver operating characteristic (ROC) curves. Results: There was no significant difference in levels of WBC, neutrophils, and lymphocytes between the two groups (P>0.05). The level of monocytes in the observation group was lower than that in the control group (P<0.05). There was no significant difference in NLR between the two groups (P>0.05). LMR in the observation group was significantly lower than that in the control group, while NMR was significantly higher than that in the control group (P<0.05). There was no significant difference in NLR between the stage I+II group and the stage III group. LMR in the stage I+II group was higher than that in the stage III group, while NMR was lower than that in the stage III group (P<0.05). Of the 116 patients with esophageal cancer, there were 32 cases (27.85%) with poor prognoses. The levels of serum NLR and NMR in the poor prognosis group were significantly higher than those in the good prognosis group, while LMR was significantly lower than that in the good prognosis group (P<0.05). AUC values of serum NLR, LMR, and NMR for predicting the prognosis of esophageal cancer were 0.766, 0.799, and 0.708, respectively (P<0.05). Taking 2.670, 4.379, and 15.896 as the cut-off values of NLR, LMR, and NMR, the sensitivity and specificity of combined detection (parallel mode) for predicting prognosis were 93.75% and 64.29%, respectively. The sensitivity of combined detection was higher than that of a single index. Conclusion: Serum NLR, LMR, and NMR are related to the prognosis of patients with esophageal cancer. The combined detection of serum NLR, LMR, and NMR levels have important clinical value in diagnosing esophageal cancer and predicting 1-year prognosis.

Key words： Lymphocyte-monocyte ratio Neutrophil-lymphocyte ratio Esophageal cancer Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.02.014 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I2/254

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