高压氧联合丁苯酞对急性脑梗死患者神经功能及血清Ang-1 THBS-1和Bcl-2水平的影响

doi:10.3969/j.issn.1006-6233.2023.12.014

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Abstract Objective: To observe the effects of hyperbaric oxygen combined with butylphthalide on neurological function and serum levels of Ang-1, THBS-1, and Bcl-2 in patients with acute ischemic stroke. Methods: A total of 112 patients with acute ischemic stroke admitted from May 2021 to January 2023 were prospectively selected as the study subjects and divided into two groups using a completely random method. Both groups received conventional medication, with 56 patients in the Butylphthalide group receiving butylphthalide treatment and 56 patients in the Hyperbaric Oxygen group receiving hyperbaric oxygen combined with butylphthalide treatment. The differences in NIHSS score, Barthel Index (BI), and modified Rankin Scale (mRS) score between the two groups were compared. Additionally, brain blood flow perfusion, levels of Ang-1, THBS-1, and Bcl-2 were detected, and treatment efficacy and adverse reactions were statistically analyzed. Results: There was no statistically significant difference in the relevant scores before treatment in both groups (P>0.05). Compared with before treatment, the NIHSS and mRS scores decreased, while the BI index increased in both the Hyperbaric Oxygen and Butylphthalide groups, with greater reductions and increases observed in the Hyperbaric Oxygen group than in the Butylphthalide group (P<0.05). There was no statistically significant difference in brain blood flow perfusion before treatment between the two groups (P>0.05). Compared with before treatment, both the Hyperbaric Oxygen and Butylphthalide groups showed an increase in cerebral blood flow (CBF) and cerebral blood volume (CBV), with a greater increase observed in the Hyperbaric Oxygen group than in the Butylphthalide group (P<0.05). There was no statistically significant difference in Ang-1, THBS-1, and Bcl-2 levels before treatment between the two groups (P>0.05). Compared with before treatment, both the Hyperbaric Oxygen and Butylphthalide groups showed an increase in Ang-1 and Bcl-2 levels, and a decrease in THBS-1 levels, with a greater increase and decrease observed in the Hyperbaric Oxygen group than in the Butylphthalide group (P<0.05). The total effective rate in the Hyperbaric Oxygen group was 94.64% (53/56), higher than the Butylphthalide group's 82.14% (46/56), and there was no statistically significant difference in adverse reactions compared to the Butylphthalide group (P>0.05). Conclusion: Hyperbaric oxygen combined with butylphthalide can improve cerebral blood flow perfusion, regulate the expression of Ang-1, THBS-1, and Bcl-2, improve neurological function, and enhance patient independence.

Key words： Hyperbaric oxygen Butylphthalein Acute cerebral infarction Cerebral blood perfusion Neural function

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	LI Na
	WANG Shengyuan
	MENG Xiangen

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LI Na,WANG Shengyuan,MENG Xiangen. Impact of Hyperbaric Oxygen Combined with Butylphthalide on Neurological Function and Serum Levels of Ang-1 THBS-1 and Bcl-2 in Patients with Acute Ischemic Stroke[J]. HeBei Med, 2023, 29(12): 2011-2016.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.12.014 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I12/2011

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