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| Correlation between Peripheral Blood Levels of miR-30a miR-24 and Sestrin2 and the Extent of Myocardial Injury in Acute Myocardial Infarction Patients |
| WANG Biao, CHEN Jianhong, WU Gang, et al |
| Liuzhou People's Hospital, Guangxi Liuzhou 545001, China |
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Abstract Objective: To explore the correlation between the expression levels of miR-30a,miR-24 and Sestrin2 in peripheral blood and the degree of myocardial injury in AMI patients in order to evaluate its potential clinical value in myocardial infarction. Methods: The study included 180 patients who were diagnosed with acute ST-segment elevation myocardial infarction between January 2020 and January 2023.A control group consisting of 100 age-matched individuals without cardiac conditions was also established.The study compared the peripheral blood levels of miR-30a,miR-24,and Sestrin2 between the two groups.Coronary angiography was performed on the patients to assess the extent of myocardial injury.Patients in the study group were categorized into mild and severe groups based on the severity of myocardial injury.The study also analyzed the correlation between peripheral blood miR-30a,miR-24,and Sestrin2 expression and levels of cardiac markers (CK,CK-MB,LDH,and hs-cTnI). Results: Compared to the control group,patients in the study group showed increased relative expression levels of miR-30a and Sestrin2,and decreased relative expression of miR-24 (P<0.05).Within the study group,patients in the severe myocardial injury group exhibited higher relative expression levels of miR-30a and Sestrin2,and lower relative expression of miR-24 compared to the mild group (P<0.05).Additionally,CK,CK-MB,LDH,and hs-cTnI levels were elevated in the severe group when compared to the mild group (P<0.05).Peripheral blood miR-30a and Sestrin2 levels were positively correlated with levels of CK,CK-MB,LDH,and hs-cTnI,while miR-24 expression was negatively correlated with these cardiac markers (P<0.05).Using the degree of myocardial injury as a variable,the study analyzed the diagnostic value of peripheral blood levels of miR-30a and miR-24 as well as Sestrin2.The AUC values for each index were 0.942,0.989,and 0.862,respectively. Conclusion: In patients with acute myocardial infarction,those with severe myocardial injury had higher levels of miR-30a and Sestrin2 and lower levels of miR-24.The study also revealed a significant correlation between the expression of peripheral blood miR-30a,miR-24,and Sestrin2 and the extent of myocardial injury.These findings suggest that these markers could serve as potential biomarkers for assessing the degree of myocardial injury in AMI patients,providing a basis for risk stratification and guiding clinical treatment decisions in AMI patients.
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[1] Damluji AA,van Diepen S,Katz JN,et al.Mechanical complications of acute myocardial infarction:a scientific statement from the American heart association[J].Circulation,2021,144(2):e16-e35.
[2] Gulati R,Behfar A,Narula J,et al.Acute myocardial infarction in young individuals[J].Myo Clin Proc,2020,95(1):136-156.
[3] 陈亚栋,梁燕芳,冼朝丽.急性心肌梗死经PCI治疗后D-二聚体、hs-CRP和LDL-C水平与预后的相关性[J].海南医学,2022,33(4):421-423.
[4] Yu H,Li Y,Zhang R,et al.Inhibition of cardiomyocyte apoptosis post-acute myocardial infarction through the efficient delivery of microRNA-24 by silica nanoparticles[J].Nanoscale Adv,2021,3(22):6379-6385.
[5] 滕丽峰,陈茜茜,叶丛,等.血清Sestrin2在急性ST段抬高型心肌梗死中的表达及其与缺血再灌注损伤的关系[J].天津医药,2023,51(3):303-306.
[6] 郭潮,刘玉琼,张慧,等.急性心肌梗死病人血清miR-30a、miR-24、miR-155水平的变化及临床意义[J].中西医结合心脑血管病杂志,2023,21(2):345-348.
[7] 白婷婷,祁华琪,聂晓东.急性心肌梗死患者血清CD137、mir-335-5p水平及其与预后的关系[J].中国循证心血管医学杂志,2021,13(6):697-700,725.
[8] 冯丽丽,李博文,田振军.运动激活SESN2/AMPK/PGC-1α通路改善心梗诱导的骨骼肌减少[J].北京体育大学学报,2021,44(5):128-137.
[9] 陈鑫森,邵萌,张天,等.血液学参数预测急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗术后发生 主要不良心血管事件的价值研究[J].中国全科医学,2020,23(27):3389-3395.
[10] Sun P,Wang C,Mang G,et al.Extracellular vesicle-packaged mitochondrial disturbing miRNA exacerbates cardiac injury during acute myocardial infarction[J].Clin Transl Med,2022,12(4):779. |
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2023, Vol. 29 
