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| Effectiveness of Isotretinoin Combined with M22-ResurFx Non-Ablative Fractional Laser in the Treatment of Severe Acne |
| CHEN Xiaoyan, ZHU Lixia, DANG Hui, et al |
| The First Affiliated Hospital of Air Force Medical University, Shaanxi Xi'an 710032, China |
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Abstract Objective: To explore the effects of isotretinoin combined with M22-ResurFx non-ablative fractional laser in the treatment of severe acne. Methods: A total of 104 patients with severe acne were selected and randomly divided into control group and observation group, with 52 cases in each group. The control group was given M22-ResurFx non-ablative fractional laser treatment, and the observation group was given isotretinoin on this basis. The clinical efficacy of the two groups was evaluated after 5 months of treatment. The skin physiological indexes (VISIA digital skin analysis indexes) and wound basal tissue biochemical indexes [vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), transforming growth factor-β activated kinase (TAK)] were compared between the two groups before treatment and after 5 months of treatment. The occurrence of adverse reactions and recurrence rate within 3 months of follow-up were recorded in both groups. Results: The total effective rate in observation group was higher than that in control group after 5 months of treatment (96.15% vs 80.77%, P<0.05). Before treatment, there were no statistical differences in the score of lactic acid sting test and scores of items of skin VISIA between the two groups (P>0.05). After 5 months of treatment, the score of lactic acid sting test in both groups was higher than that before treatment (P<0.05) while the five VISIA scores of redness zone, sclererythrin, spot, texture, and pore were lower compared with those before treatment (P<0.05), and the differences of the above indicators in observation group were greater than those in control group (P<0.05). There were no statistically significant differences in the levels of VEGF, TGF-β1 and TAK in wound basal tissue between both groups before treatment (P>0.05), and the above levels in the two groups after treatment were significantly decreased (P<0.05), and the differences in observation group were greater compared to control group (P<0.05). There was no statistical significance in the total incidence rate of adverse reactions between the two groups (15.38% vs 17.31%, P>0.05). The recurrence rate in observation group was significantly lower than that in control group (1.92% vs 13.46%, P<0.05). Conclusion: Isotretinoin combined with M22-ResurFx non-ablative fractional laser has significant efficacy in the treatment of severe acne, and it can significantly improve the acne severity and skin physiological indexes, and can inhibit the levels of VEGF, TGF-β1 and TAK in wound basal tissue to reduce the acne scar regeneration, and it does not increase adverse reactions, and it has low recurrence rate and good safety.
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2023, Vol. 29 
