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| Changes and Significance of T Lymphocyte Subsets, B Cells and NK Cells in Infertility Patients with Cervical High-Risk HPV Infection |
| LI Rong, GAO Xiaoyu, WANG Xin, et al |
| The Second Affiliated Hospital of Air Force Military Medical University, Shaanxi Xi'an 710038, China |
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Abstract Objective: To investigate the changes and significance of T lymphocyte subsets, B cells, and natural killer (NK) cells in infertility patients with high-risk cervical human papilloma (HPV) infection. Methods: The clinical data of 1,150 infertility patients with cervical high-risk HPV infection (study group) and 580 HPV-negative infertility patients (control group) who were treated in the gynecology department at the hospital between November 2019 and October 2020 were collected retrospectively. The changes in T lymphocyte subsets, B cells, and NK cells were compared between the two groups. The relationship of the above-mentioned indicators with subtypes of HPV infection and grades of cervical lesions was analyzed. Results: There were no significant differences in the proportions of CD3+ and B cells between the two groups (P>0.05). The proportions of CD4+, CD4+/CD8+, and NK cells in the study group were lower than those in the control group, and the proportion of CD8+ was higher than that in the control group (P<0.05). In the study group, the proportion of HPV 16/18 infected patients was higher than patients infected with other subtypes, and the proportion of HPV 16/18 was significantly different in patients with different grades of HPV infection (P<0.05). The proportions of CD4+, CD4+/CD8+, and NK cells in HPV 16/18 infected patients were lower than those in patients infected with other subtypes, and the proportion of CD8+ was higher than that in patients infected with other subtypes (P<0.05). The proportions of CD3+ and B cells showed no significant differences between patients infected with different subtypes of HPV (P>0.05). With the progression of cervical lesions, the proportions of CD4+, CD4+/CD8+, and NK cells decreased, while the proportion of CD8+ increased (P<0.05), but no significant changes in the proportions of CD3+ and B cells were observed (P>0.05). Conclusion: High-risk HPV-infected infertility patients are accompanied by a certain degree of immune dysfunction. Clinically, changes in the proportions of T lymphocyte subsets, B cells, and NK cells can be detected to provide an objective basis for clinical assessment of HPV subtypes and the progression of cervical lesions.
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2023, Vol. 29 
