牛碱性成纤维细胞生长因子治疗烧伤性瘢痕的效果及作用机制分析

doi:10.3969/j.issn.1006-6233.2023.10.006

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Abstract Objective: To investigate the effect and mechanism of dot-matrix laser combined with bovine basic fibroblast growth factor in the treatment of burn scarring. Methods: A total of 158 cases of post-burn scarring patients treated in our hospital from January 2021 to July 2022 were selected, and the patients were randomly divided into 79 cases each in the combined group and the control group using a simple random grouping method (randomized numerical table method). In terms of basic treatment measures, the patients in the control group received fractional laser treatment at the same time, and the combined group received bovine basic fibroblast growth factor (BBGF) treatment for 4 consecutive weeks on top of the control group treatment. The combination group received bovine basic fibroblast growth factor (BFGF) on top of the treatment in the control group for 4 consecutive weeks, and compared the levels of transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 7 (BMP-7) in the scar tissues of the two groups before and after treatment, as well as the scores of the Vancouver Scar Scale (VSS), the Scar Evaluation Scale (PSAS), and the differences in the clinical efficacy and the incidence of adverse reactions. Results: Before treatment, there was no statistically significant difference in the levels of TGF-β1, BMP-7, PSAS score, scar color, blood vessel distribution, scar thickness, and softness score of scar in the scar tissues of patients in the combined group and the control group (P>0.05); after treatment, the levels of TGF-β1 in the scar tissues of the patients in the two groups were reduced, and the levels of BMP-7 increased, and the difference was statistically significant ( P<0.05); comparing the difference between the two groups before and after treatment, the decrease of TGF-β1 and the increase of BMP-7 in the combined group were greater than that in the control group, and the difference was statistically significant (P<0.05); after treatment, the scar color, vascular distribution, scar thickness, scar softness score, and PSAS score of the patients in the two groups were reduced, and the decrease of the combined group was greater than that of the control group, and the differences between the above indexes were statistically significant (P<0.05). The differences between the groups were statistically significant (P<0.05); after treatment, the overall distribution of efficacy of the patients in the combined group was better than that of the control group, and the difference was statistically significant (P<0.05); in the course of treatment, the complication rate of the combined group was 7.59%, and that of the control group was 20.25%, and the difference between the two groups was statistically significant (P<0.05). Conclusion: For patients with burn scar formation, the use of fractional laser + bovine basic fibroblast growth factor treatment has significant and reliable clinical efficacy, and can significantly promote and improve the state of scar tissue proliferation and the aesthetic degree of the patient's appearance, which is worthy of clinical promotion.

Key words： Burn Lattice laser Bovine basic fibroblast growth factor Scar Transforming growth factor β1 Bone Morphogenetic Protein 7

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	XUE Ping
	YANG Qing
	FAN Xing
	et al

Cite this article:

XUE Ping,YANG Qing,FAN Xing, et al. Analysis of the Therapeutic Effect and Mechanism of Bovine Basic Fibroblast Growth Factor on Burn Scarring[J]. HeBei Med, 2023, 29(10): 1617-1623.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.10.006 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I10/1617