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| Microbiological cCharacteristics and pPredictive vValue of CPIS and SOFA sScores in COPD pPatients with VAP |
| LI Shiliang, MA Dongmei XIANG Xiaobo |
| The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100029, China |
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Abstract Objective: To investigate the microbiological characteristics and the predictive value of Clinical Pulmonary Infection Score (CPIS) and Sequential Organ Failure Score (SOFA) in patients with chronic obstructive pulmonary disease (COPD) complicated by ventilator-associated pneumonia (VAP). Methods: A total of 136 COPD patients admitted to our hospital from November 2019 to November 2021 were selected and divided into study group (n=60) and reference group (n=76) according to whether the patients had VAP or not, and 50 healthy subjects during the same period were selected as the control group. The baseline characteristics and CPIS and SOFA scores of the three groups of patients with different prognosis were compared, and the multi-factors associated with VAP-related pathogen resistance, COPD combined with VAP and poor prognosis were analyzed; the predictive value of CPIS, SOFA and combined scores on the prognosis of COPD combined with VAP was analyzed. Results: Diabetes, pulmonary tuberculosis, multiple hospitalizations due to COPD, and antibiotic use within 3 months in the study group were higher than those in the reference group, and the CPIS and SOFA scores were higher than those in the reference group, which were risk factors for COPD complicated with VAP (P<0.05); the resistance rate of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii to imipenem and imipenem was less than 10%, and the drug resistance rate was low; the CPIS and SOFA scores in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05); CPIS and SOFA scores were risk factors for poor prognosis of COPD combined with VAP (P<0.05); the AUC of CPIS combined with SOFA score in predicting the prognosis of COPD combined with VAP was higher than that of CPIS and SOFA score (P<0.05). Conclusion: Elevated CPIS and SOFA scores are risk factors and prognostic risk factors for COPD complicated with VAP. VAP antimicrobial therapy should be administered according to the drug sensitivity results, and combined evaluation is beneficial to the prognosis of patients.
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2023, Vol. 29 
