银杏叶提取物注射液联合多哌奈齐治疗老年血管性痴呆的效果及对认知功能氧化应激反应的影响

doi:10.3969/j.issn.1006-6233.2022.09.036

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1224 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the effect of extract of ginkgo biloba leaves injection combined with donepezil on senile vascular dementia and its influence on cognitive function and oxidative stress. Methods: The data of 90 aged patients who had vascular dementia treatment in our hospital from May 2019 to December 2021 were retrospectively analyzed. All patients were divided into two groups, the observation group (n=45) and the control group (n=45), according to different treatment methods. People in the control group were administered donepezil hydrochloride tablets, while the people in the observation group were administered extract of ginkgo biloba leaves injection combined with donepezil hydrochloride tablets. All patients were treated continuously for 2 months. The therapeutic effect, cognitive function, self-care ability, and indexes related to oxidative stress were compared before and after treatment. Results: The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the scores on the MMES scale and Barthel index in the two groups were significantly higher than those before treatment. After treatment, the contents of serum homocysteine (Hcy), interferon-γ (IFN-γ), and malondialdehyde (MDA) in both groups were significantly lower than those before treatment, while the contents of superoxide dismutase (SOD) in both groups were significantly higher than those before treatment. Conclusion: Extract of ginkgo biloba leaves injection combined with doxepinezi can improve the cognitive function of elderly patients with vascular dementia, improve self-care ability, and reduce the content of oxidative stress reaction index. The therapeutic effect is remarkable, and it is worthy of clinical application.

Key words： Ginkgetin glycoside Dopenezil extract of ginkgo biloba leaves injection Cognitive function Oxidative stress reaction

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	PENG Fei
	WANG Ruiping
	ZHANG Wei
	et al

Cite this article:

PENG Fei,WANG Ruiping,ZHANG Wei, et al. Effectiveness of Extract of Ginkgo Biloba Leaves Injection Combined with Doperidonezide in the Treatment of Vascular Dementia in the Elderly and Its Effect on Cognitive Function and Oxidative Stress Response[J]. HeBei Med, 2022, 28(9): 1577-1581.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.09.036 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I9/1577

[1] 谌雪梅,曾兆兰,蒲卢兰,等.老年痴呆照顾者与患者生活质量的相关性分析[J].成都医学院学报,2021,16(5):5.
[2] 许平英,刘悦.自拟益智祛痰通窍汤辅助治疗老年血管性痴呆的效果观察[J].青岛医药卫生,2021,53(6):408-411.
[3] 黄婉玲,赖冬琴.多奈哌齐联合丁苯酞治疗老年血管性痴呆的应用效果[J].中外医学研究,2021,19(31):71-74.
[4] 中国医师协会神经内科分会认知障碍专业委员会,《中国血管性认知障碍诊治指南》编写组.2019年中国血管性认知障碍诊治指南[J].中华医学杂志,2019,99(35):2737-2744.
[5] 韩亚军,康蓓,王晓明.多奈哌齐联合丁苯酞治疗老年血管性痴呆的临床效果及对血液流变学的影响[J].临床医学研究与实践,2021,6(23):39-41.
[6] 刘文广,吴丽媛,韩露,等.冠心宁联合辛伐他汀治疗老年血管性痴呆患者的临床研究[J].中国临床药理学杂志,2021,37(17):2251-2254.
[7] 周艳,张捷,刘虹艳.针刺联合西药治疗老年血管性痴呆的临床观察[J].中国民间疗法,2021,29(19):65-68.
[8] 徐晓今,李岩松,李东文.丁苯酞联合依达拉奉治疗老年血管性痴呆的临床分析[J].老年医学与保健,2021,27(5):1007-1010,1018.
[9] 杜灵枝,张方,刘静静.美金刚与多奈哌齐治疗老年血管性痴呆的比较研究[J].药物评价研究,2020,43(10):2031-2034.
[10] 李芯,宋艳荣.银杏叶提取物制剂序贯疗法对老年血管性痴呆患者记忆、认知及血流状态的影响[J].中国药物经济学,2021,16(2):66-69.
[11] 张会芹,李浩,韦云.血管性痴呆神经功能缺损预测因子的研究进展[J].中西医结合心脑血管病杂志,2020,18(16):2612-2614.
[12] 黄妍,王洁,张军,等.老年血管性痴呆患者血清Lp-PLA2、S100β及尿液AD7C-NTP与认知功能的相关性[J].国际检验医学杂志,2021,42(10):1246-1249.