金天格胶囊联合骨化三醇对骨质疏松性椎体压缩性骨折患者的应用效果分析

doi:10.3969/j.issn.1006-6233.2022.09.035

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Abstract Objective: To analyze the effect of Jintiange capsule combined with calcitriol in patients with osteoporotic vertebral compression fracture (OVCF). Methods: Totally 150 patients with OVCF admitted to our hospital from January 2017 to June 2021 were randomly divided into the combined group and the control group with 75 cases in each group. Patients in both groups received percutaneous vertebroplasty (PVP), the control group was given calcitriol orally after the operation, and the combined group was given Jintiange capsule orally for 6 months. The changes in the visual analog scale of pain (VAS), Oswestry dysfunction index (ODI), the height of the anterior edge of the vertebral body, Cobb angle of injured vertebral body, bone mineral density, and bone metabolism index were compared between the two groups. Results: Six months after treatment, the VAS score, ODI index, Cobb angle, and RANKL of the two groups decreased compared with those before the operation, while the height of the vertebral front, the bone mineral density of L1~L4, the bone mineral density of femoral neck and OPG increased. The VAS score, ODI index, Cobb angle, RANKL, the height of the anterior edge of the vertebral body, the bone mineral density of L1~L4, the bone mineral density of the femoral neck, and OPG in the group were all higher than those in the control group at 6 months after combined treatment, and the difference was statistically significant (P<0.05). Conclusion: Based on oestriol, the combination of Jintiange capsules in the postoperative adjuvant treatment of OVCF patients with PVP not only helps to alleviate patients' clinical symptoms and promotes the recovery of vertebral height but also improves patients' bone density and bone metabolism, achieving both symptomatic and primary treatment.

Key words： Jintiange capsule Calcitriol Osteoporotic vertebral compression fracture Bone metabolism

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.09.035 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I9/1573

[1] 陈伟健,谢炜星,晋大祥,等.胸腰段骨质疏松性椎体压缩性骨折有限元模型的建立[J].山东医药,2018,58(32):55-58.
[2] Wang B,Zhao C P,Song L X,et al.Balloon kyphoplasty versus percutaneous vertebroplasty for osteoporotic vertebral compression fracture:a meta-analysis and systematic review[J].Journal of orthopaedic surgery and research,2018,13(1):1-8.
[3] 任志伟,尹思,王莹,等.经皮椎体后凸成形术治疗多节段骨质疏松性椎体压缩性骨折的疗效分析[J].实用骨科杂志,2018,24(7):633-637.
[4] 苏其昌,张汉庆,王晓慧.经皮球囊扩张椎体后凸成形术与保守治疗骨质疏松性椎体压缩性骨折的Meta分析[J].江汉大学学报:自然科学版,2018,46(1):77-82.
[5] Sun M,Hu L,Wang S,et al.Circulating microRNA-19b identified from osteoporotic vertebral compression fracture patients increases bone formation[J].Journal of Bone and Mineral Research,2020,35(2):306-316.
[6] 邢帅,杨勇,王永刚,等.脊柱骨盆矢状面平衡对骨质疏松性椎体压缩性骨折经皮椎体后凸成形术后继发骨折的影响[J].中华创伤骨科杂志,2018,20(6):487-491.
[7] Zhao W T,Qin D P,Zhang X G,et al.Biomechanical effects of different vertebral heights after augmentation of osteoporotic vertebral compression fracture:a three-dimensional finite element analysis[J].Journal of orthopaedic surgery and research,2018,13(1):1-10.
[8] Huang S,Zhu X,Xiao D,et al.Therapeutic effect of percutaneous kyphoplasty combined with anti-osteoporosis drug on postmenopausal women with osteoporotic vertebral compression fracture and analysis of postoperative bone cement leakage risk factors:a retrospective cohort study[J].Journal of orthopaedic surgery and research,2019,14(1):1-12.
[9] 项廷淼,殷世武,李靖,等.高黏度骨水泥治疗骨质疏松性椎体压缩性骨折的临床疗效观察[J].中国医学前沿杂志,2018,10(9):43-46.
[10] Jin Y Z,Lee J H,Xu B,et al.Effect of medications on prevention of secondary osteoporotic vertebral compression fracture,non-vertebral fracture,and discontinuation due to adverse events:a meta-analysis of randomized controlled trials[J].BMC musculoskeletal disorders,2019,20(1):1-17.
[11] Kim H J,Park S,Park S H,et al.Prevalence of frailty in patients with osteoporotic vertebral compression fracture and its association with numbers of fractures[J].Yonsei medical journal,2018,59(2):317-324.
[12] 李素艳,赵军红.骨质疏松性椎体压缩性骨折术后生活质量及危险因素分析[J].哈尔滨医药,2021,41(1):48-49.
[13] Ameis A,Randhawa K,Yu H,et al.The global spine care initiative:a review of reviews and recommendations for the non-invasive management of acute osteoporotic vertebral compression fracture pain in low-and middle-income communities[J].European Spine Journal,2018,27(6):861-869.
[14] Chiu P Y,Kao F C,Hsieh M K,et al.A retrospective analysis in 1347 patients undergoing cement augmentation for osteoporotic vertebral compression fracture:is the sandwich vertebra at a higher risk of further fracture[J].Neurosurgery,2021,88(2):342-348.