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Changes of Serum IGF-1,IGFBP-3 and Hcy Levels in Children with Congenital Hypothyroidism and Their Relationship with Physical Development |
PENG Guimei, et al |
Hainan Modern Women's and Children's Hospital, Hainan Haikou 571100, China |
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Abstract Objective: To investigate the changes in serum insulin growth factor-1 (IGF-1),insulin-like growth factor binding protein-3 (IGFBP-3) and homocysteine (Hcy) levels in children with congenital hypothyroidism (CH) and their relationship with physical development. Methods: One hundred and ten children with CH who received replacement therapy at our hospital (observation group) and 59 normal newborns at the same time (healthy control group) were selected as study subjects.Both groups were followed up for 1 year.The differences in levels of serum IGF-1,IGFBP-3 and Hcy and physical development indicators [height,body mass,height standard deviation score (HtSDS),weight standard deviation score (WTSDS)] were compared between observation group and healthy control group at enrollment and after 1 year of follow-up.Pearson correlation analysis was used to analyze the correlation between levels of serum IGF-1,IGFBP-3 and Hcy and physical development indicators of children patients with CH after 1 year of follow-up. Results: There were no significant differences between the two groups in terms of gender,age,delivery methods and maternal birth age (all P>0.05),and the TSH level of observation group was significantly higher than that of healthy control group (P<0.05) while the levels of FT3 and FT4 were significantly lower than those in control group (P<0.05).The levels of IGF-1 and IGFBP-3 in observation group and healthy control group after 1 year of follow-up were higher than those at enrollment (P<0.05) while the level of Hcy was significantly lower than that at enrollment (P<0.05).At enrollment and after 1 year of follow-up,the levels of serum IGF-1 and IGFBP-3 in observation group were lower than those in healthy control group (P<0.05) while the level of serum Hcy was higher (P<0.05).At enrollment,there were no statistically significant differences in the height,body mass,HtSDS and WTSDS between the two groups (P>0.05).The height and body mass in observation group and healthy control group after 1 year of follow-up were higher than those at enrollment (P<0.05),and the height and body weight of healthy control group were higher or heavier than those of observation group (P<0.05).According to Pearson correlation analysis,levels of serum IGF-1,IGFBP-3 and Hcy in children with CH were not correlated with HtSDS and WTSDS (P>0.05),but levels of IGF-1 and IGFBP-3 were positively correlated with height and body mass (all P<0.05),and Hcy level was negatively correlated with height and body mass (all P<0.05). Conclusion: The levels of serum IGF-1,IGFBP-3 and Hcy in children with CH after replacement therapy have been significantly improved,and they have a significant correlation with physical development.
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[1] 张骥,李杨.新生儿先天性甲状腺功能减低症危险因素的Meta分析[J].中国当代儿科杂志,2021,23(5):505-512. [2] 阎亚琼,李永红,杨建平,等.先天性甲状腺功能减低症患儿血清25-羟维生素D营养状况分析[J].中国药物与临床,2022,22(2):142-144. [3] 张聪.早产儿甲状腺功能障碍的研究进展[J].国际儿科学杂志,2022,49(1):52-57. [4] 张雪梅,谢邦贵,陈小冰,等.先天性甲状腺功能减低症45例影响因素分析[J].中国儿童保健杂志,2021,29(11):1233-1236,1268. [5] 唐禹馨,吕芸,丁海燕.妊娠期亚临床甲状腺功能减退血清同型半胱氨酸和维生素B12与叶酸水平变化及相关性分析[J].中国慢性病预防与控制,2019,27(1):58-60. [6] 中华预防医学会儿童保健分会新生儿疾病筛查学组.先天性甲状腺功能减低症诊疗共识[J].2011年第11届中华医学会儿科学分会内分泌遗传代谢学组学术会议,2011,49(6):421-423. [7] 瞿准,赵建华,王超,等.甲状腺激素在急性脑卒中患者中的应激变化及与预后的关系[J].河北医药,2020,42(12):1801-1804. [8] 王琼,齐志业,赵小龙,,等.2016年至2019年先天性甲状腺功能减低症筛查质量分析[J].中国妇幼健康研究,2020,31(10):1349-1354. [9] 殷欣欣,崔照领,马丽静,等.IGF-2、IGFBP-3在胎儿生长受限患者胎盘组织中的表达及其临床意义[J].生殖医学杂志,2021,30(3):377-383. [10] 符艺影,邢东文,王华,等.特发性矮小儿童血清IGF-1和IGFBP-3水平与生长体格的关系[J].临床和实验医学杂志,2020,19(16):1692-1697. [11] 王秀丽,颜珊,方建红.妊娠合并甲状腺功能减退患者血清TSH、叶酸、Hcy表达水平及其临床意义[J].中国妇产科临床杂志,2021,22(3):240-242. [12] 谢明林.妊娠合并甲状腺功能减退患者血清同型半胱氨酸、维生素B_(12)的表达水平及其与母婴预后的关系[J].中国妇幼保健,2019,34(2):286-289. [13] 李艳艳,赵旭敏.妊娠期亚临床甲减TPOAb阴性孕妇不同时间左甲状腺素钠片治疗对妊娠结局及幼儿神经功能影响[J].中国计划生育学杂志,2021,29(7):1383-1387. |
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