半夏泻心汤联合荆花胃康胶丸对慢性萎缩性胃炎患者CA724 PG1水平的影响

doi:10.3969/j.issn.1006-6233.2022.08.036

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Abstract Objective: To analyze the effect of Banxia Xiexin Decoction combined with Jinghua Weikang capsule on CA724 and PG1 levels in patients with chronic atrophic gastritis. Methods: A total of 100 patients with chronic atrophic gastritis admitted to our hospital from October 2019 to October 2021 were selected as the research objects, and they were divided into control group and research group, 50 cases in each. Control group was given Jinghua Weikang capsule, study group was given Banxia Xiexin Decoction combined with Jinghua Weikang capsule. The levels of CA724, PG1, inflammatory factors and gastric mucosa function related indicators in the two groups were detected, and the TCM symptom scores, adverse reactions and clinical efficacy were compared between the two groups. Results: Comparison of dry mouth and bitter taste, epigastric fullness, epigastric fullness, nausea and vomiting, CA724, PG1, IL-6, IL-1β, TNF-α, PGE2, GSH-px between the two groups before and after treatment. Dry mouth, stomach fullness, epigastric fullness, nausea and vomiting scores, CA724, IL-6, IL-1β, TNF-α levels decreased more than the control group, and PG1, PGE2, GSH-px levels increased more than the control group group (P<0.05). The adverse effects were slightly higher than the control group (P>0.05), and the treatment response rate was higher than the control group (P<0.05). Conclusion: After combined treatment with Banxia Xiexin Decoction and Jinghua Weikang Capsules, the levels of CA724 and inflammatory factors in patients with chronic atrophic gastritis decreased, the level of PG1 increased, and the gastric mucosal function improved.

Key words： Chronic atrophic gastritis Jinghua weikang capsule Pinellia purgatory decoction Carbohydrate antigen 724 Pepsinogen I

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.08.036 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I8/1404

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