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| Effects of Different Doses of Ticagrelor Combined with Atorvastatin Calcium Tablets on Hemorheology Cardiac Function and Serum MMP-9 and IGF-1 in Patients with Coronary Heart Disease UAP |
| WANG Wenjuan, LI Gonghui, et al |
| Zhujiang Hospital, Southern Medical University, Guangdong Guangzhou 510510, China |
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Abstract Objective: To explore the effects of different doses of ticagrelor combined with atorvastatin calcium tablets on hemorheology, cardiac function and serum matrix metalloprotein-9 (MMP- 9), the effect of insulin-like growth factors-1 (IGF-1). Methods: A total of 117 patients with coronary heart disease UAP who were treated in our hospital from November 2020 to November 2021 were prospectively selected as the research subjects, and were divided into groups A and B by simple random coin tossing method, and finally 61 patients in group A and 56 patients in group B were included. The patients in group B were given 90mg ticagrelor + atorvastatin calcium tablets on the basis of conventional treatment, and the patients in group A were given 45mg ticagrelor + atorvastatin calcium tablets on the basis of conventional treatment , the two groups of patients were treated continuously for 1 month. The rheology (whole blood viscosity (WBV), plasma viscosity (PV)), cardiac function (left ventricular ejection fractions (LVEF), left ventricular end diastolic diameter (LVEDD) and serum MMP-9, LVEDD) were compared between the two groups before and after 1 month of treatment(LVEF), left ventricular end diastolic diameter (LVEDD), interventricular septum thickness (IVST)) and serum MMP-9 and IGF-1 levels. Results: The results of repeated measures variance showed that the comparison between the WBV and PV levels at different points of treatment in both groups was statistically significant with time factor as the source, between-subjects effect with group as the source and within-subjects effect with time and group interaction as the source, P<0.05; after 1 month of treatment, the WBV and PV levels decreased in both groups and were lower in group A than in group B, P<0.05; The results of repeated measurement variance showed that the comparison of LVEF, LVEDD, and IVST levels at different points of treatment in both groups was statistically significant with time factor as the source, between-subjects effect with group as the source and within-subjects effect with time and group interaction as the source, P<0.05; after 1 month of treatment, LVEF levels increased in both groups and were higher in group A than in group B, LVEDD and IVST levels decreased and were lower in group A than in group B, P<0.05. Repeated measurement variance results showed that the two groups of patients were not treated well. At the same time, the MMP-9 and IGF-1 levels at the same time points were compared between the inter-subject effect with the time factor as the source, the group as the source, and the intra-subject effect with the interaction between time and group as the source, P<0.05; after one month treatment, the levels of MMP-9 in both groups decreased and lower in group A than in group B, while the levels of IGF-1 increased and higher in group A than in group B, P<0.05.Conclusion: Different doses of ticagrelor combined with atorvastatin calcium tablets have certain therapeutic effects on patients with coronary heart disease UAP, but the patients in the low-dose group have better improvement in blood rheology and cardiac function, and can significantly reduce MMP-9 And improve the level of IGF-1, which is worthy of clinical reference.
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2022, Vol. 28 
