宫颈癌患者化疗前后宫颈上皮组织Bcl-2和MACCI蛋白表达及ROC预测效能

doi:10.3969/j.issn.1006-6233.2022.08.025

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Abstract Objective: To explore the expression of B lymphocyte tumor-2 gene (Bcl-2) and colon cancer metastasis related gene 1 protein (MACCI) in cervical epithelial tissue before and after chemotherapy in patients with cervical cancer. Methods: The retrospective analysis of 89 cervical intraepithelial neoplasia (cervical neoplasia group) and 121 cervical cancer patients (cervical cancer group) were collected between March 2018 and November 2020, all of whom underwent chemotherapy intervention, and MACCI and Bcl-2 expression were detected using the immunohistochemical SP method, and after comparing the gene protein expression of the two groups, the Bcl-2 and MACCI gene expression of cervical cancer patients before and after chemotherapy was then compared, and the predictive efficacy of Bcl-2 and MACCI was analysed by ROC curve. Results: The MACCI expression (7.68 ± 1.58)% and Bcl-2 expression (0.29 ± 0.04)% were higher in cervical cancer patients than in the cervical neoplasia group (P<0.05), and ROC curve analysis showed that MACCI and Bcl-2 predicted cervical cancer with AUC values of 0.924 and 0.968, respectively. meanwhile, MACCI expression (5.98 (±1.44)% and Bcl-2 expression (0.21±0.03)% were lower than those before chemotherapy (P<0.05), and the efficacy was positively correlated with MACCI and Bcl-2 by Spearman method analysis; ROC curve analysis showed that the AUC values of MACCI and Bcl-2 for diagnosing cervical cancer were 0.924 and 0.968, respectively; the AUC values of MACCI and Bcl-2. Conclusion: Bcl-2 and MACCI are more effective in the assessment of cervical cancer incidence and regression.

Key words： Cervical cancer Chemotherapy B lymphocyte tumor-2 gene Colon cancer metastasis related gene 1 protein

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	FAN Yu
	DENG Han
	TANG Bin

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FAN Yu,DENG Han,TANG Bin. Bcl-2 and MACCI Protein Expression in Cervical Epithelial Tissue Before and After Chemotherapy in Patients with Cervical Cancer and the Predictive Efficacy of ROC[J]. HeBei Med, 2022, 28(8): 1353-1356.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.08.025 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I8/1353

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