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| Expression and Clinical Significance of OPN TIMP-2 and STAT3 Proteins in Patients with Endometriosis |
| CHEN Guansheng, ZHENG Rong |
| Beijing Jishuitan Hospital, Beijing100035, China |
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Abstract Objective: To analyze the expression and clincal significance of osteopontin (OPN), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) and signal transducer and activator of transcription 3 (STAT3) proteins in endometriosis (Endometriosis, EMS) patients.Methods: Clinical data of 117 patients with endometriosis admitted to our hospital from January 2019 to January 2020 were selected [EMS group, according to the American Fertility Society scoring standard (r-AFS) staging, 53 cases in stages I-II and 64 cases in stages III-IV; menstrual cycle: 66 cases in the proliferative phase and 51 cases in the secretory phase], and another 117 cases admitted to the same period with uterine 103 non-EMS patients with fibroids or infertility treated surgically (control group) were selected. The expression of OPN, TIMP-2 and STAT3 in different populations, different r-AFS stages and different menstrual cycles were compared, and the correlation between OPN, TIMP-2 and STAT3 and r-AFS stages was analyzed.Results: The expression of OPN and STAT3 in EMS group was significantly higher than that in control group, while the level of TIMP-2 was significantly lower than that in control group (P<0.05); the expression of OPN and STAT3 in stage III-IV was significantly higher than that in stage I-II, while the level of TIMP-2 was significantly lower than that in stage I-II (P<0.05); the expression of OPN and STAT3 in proliferative stage was significantly higher than that in secretory stage, while the TIMP-2 levels were significantly lower than those in the secretory phase (P<0.05); serum OPN and STAT3 were positively correlated with r-AFS stage, and TIMP-2 was negatively correlated with r-AFS stage in EMS patients (P<0.05). Conclusion: OPN and STAT3 expression were increased and TIMP-2 expression was down-regulated in EMS patients, which were closely related to the occurrence and progression of the disease, and monitoring their expression could provide a reference for disease development prediction and regression.
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2022, Vol. 28 
