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| Association of ACE and Arg16Gly Genes with Clinical Prognosis and Treatment Response in Children with Asthma |
| LIU Dingxiang |
| Suining Central Hospital, Sichuan Suining 629000, China |
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Abstract Objective: To analyze the relationship between ACE and Arg16Gly genes and clinical prognosis and treatment response of children with asthma. Methods: A total of 140 children with asthma admitted to our hospital from January 2020 to January 2021 were screened, and the genes related to asthma in oral mucosa cells were detected by DNA sequencing and fluorescent quantitative polymerase chain reaction (PCR). The clinical prognosis characteristics of children with different types of gene mutations and the response to glucocorticoid treatment were compared, and the value of non-invasive detection of asthma genes in children to guide clinical prognosis evaluation and rational drug use were analyzed. Results: The ACE I/D genotype of 140 children was DD, and the dominance ratio of D gene to I gene was 1.98. Adr2arg16Gly genotype is mainly AG, and the dominance ratio of G gene to A gene is 1.89. The disease control rate and total effective rate of ACE I/D genotype DD children are lower than those of type II and ID children. The disease control rate and total effective rate of children with ADR2ARG16Gly genotype GG are lower than those of children with AA and AG genotype. Conclusion: There are significant differences in the expression of SNP in asthma gene-related sites in children with asthma, and it is closely related to the clinical prognosis and drug treatment response of children. Children with ACE I/D genotype DD type and ADRB2 Arg16Gly genotype GG type generally have poor clinical prognosis and limited response to glucocorticoid treatment.
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2022, Vol. 28 
