基于4D-CT扫描的调强适形放疗联合TACE对直肠癌肝转移患者预后的影响

doi:10.3969/j.issn.1006-6233.2022.06.04

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Abstract Objective: To analyze the effect of intensity modulated radiation therapy (IMRT) based on four dimensional computed tomography (4D-CT) scan combined with transarterial chemoembolisation (TACE) on prognosis of patients with rectal liver metastasis. Methods: Seventy patients with rectal liver metastasis treated in our hospital from January 2018 to July 2019 were prospectively enrolled for the research and divided into observation group and control group by simple random method, with 35 cases in each group. On the basis of whole-body radiotherapy, the observation group and the control group were treated with IMRT based on 4D-CT scan combined with TACE and IMRT based on 3D-CT scan combined with TACE respectively. The clinical efficacy and safety were compared between two groups. Results: The time of progression of observation group was significantly higher than that of control group (P<0.05). And there were no significant differences in ORR, DCR, 2-year survival rate and the incidence of adverse reactions between two groups (P>0.05). Conclusion: IMRT based on 4D-CT scan combined with TACE is a safe and effective method for patients with rectal liver metastasis, and its effect of delaying tumor progression is better than IMRT based on 3D-CT scan combined with TACE.

Key words： Intensity modulated radiation therapy Four dimensional computed tomography Chemoembolisation Rectal cancer

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.06.04 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I6/896