|
|
|
| Effects of Creatine Phosphate Sodium Combined with Trimetazidine on Structural Changes and Cardiac Serological Parameters in Patients with Acute Cardiac Insufficiency |
| ZHANG Huiwen, ZHOU Ming |
| Zhujiang Hospital Affiliated to Southern Medical University, GuangdongGuangzhou 510000, China |
|
|
|
|
Abstract Objective: To investigate the effects of creatine phosphate and trimetazidine on cardiac structural changes and cardiac serological paremeters in patients with acute cardiac insufficiency. Methods: A total of 106 patients with acute cardiac insufficiency in our hospital were randomly divided into control group (conventional drug treatment) and experimental group (conventional drug treatment + creatine phosphate + trimetazidine), 53 cases in each group. Heart rate, cardiothoracic ratio, cardiac serological index, left ventricular structure index, oxidative stress index and adverse reactions were compared between the two groups before and after treatment. Results: Compared with the control group, the cardiothoracic ratio, interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), serum B-type natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP) and malondialdehyde in the experimental group were significantly lower than those in the control group, while the left ventricular ejection fraction (LVEF) and superoxide dismutase (SOD) were significantly increased (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Combined application of creatine phosphate and trimetazidine can effectively improve cardiac structural changes and cardiac serological parameters in patients with acute ardiac insufficiency, and achieve significant therapeutic effect, and the combination of them is safe and reliable.
|
|
|
|
|
|
[1] 刘涛,徐通达.红细胞分布宽度对急性心力衰竭患者短期死亡风险的预测价值:MIMIC-Ⅲ数据库的回顾性分析[J].中国心血管杂志,2021,26(5):5.
[2] 李博,牛炳英,王芙蕊,等.小剂量多巴胺联合磷酸肌酸钠治疗小儿肺炎并心力衰竭临床研究[J].中国药业,2020,29(12):87-89.
[3] 葛均波,徐永健.内科学[M].第8版.北京:人民卫生出版社,2013.236.
[4] 倪秋明,林苗,王军,等.不同剂量曲美他嗪治疗冠心病心力衰竭的疗效研究[J].心脑血管病防治,2019,19(2):177-179.
[5] 马科,寇艳,卢蓉,等.磷酸肌酸钠治疗小儿病毒性心肌炎的疗效及对心肌酶和肌钙蛋白水平的影响[J].河北医学,2020,26(2):4.
[6] 王协涛,侯建云,李艳萍,等.磷酸肌酸钠在心肌梗死患者急救中的应用时机探讨[J].中国急救复苏与灾害医学杂志,2020,15(6):648-650,661.
[7] Moreira L P,Rocco D,Silva A,et al.Detecting creatine excreted in the urine of swimming athletes by means of Raman spectroscopy[J].Lasers in Medical Science,2020,35(2):455-464.
[8] Moreira L P,Rocco D,Silva A,et al.Detecting creatine excreted in the urine of swimming athletes by means of Raman spectroscopy[J].Lasers in Medical Science,2020,35(2):455-464.
[9] Griffiths J,Shaw S.Glyceraldehyde-phosphate dehydrogenase (total and isoenzyme activity) in the early diagnosis of myocardial infarction[J].Clinical Chemistry,2019,20(2):2. |
|
|
|
2022, Vol. 28 
