呼出气一氧化氮检测在亚急性咳嗽临床诊治中的意义

doi:10.3969/j.issn.1006-6233.2022.05.031

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Abstract Objective: To investigate the clinical value of exhaled nitric oxide (FeNO) in the diagnosis and treatment of subacute cough. Methods: 171 patients with subacute cough in respiratory medicine department of our hospital were selected to detect exhaled nitric oxide, and the results were analyzed. Results: The mean FeNO value of 171 patients was 36.89 ± 12.35, of which 47.95% were normal, 18.13% were intermediate and 33.92% were high. Among the 171 patients, there were 62 patients with pic, with an average FeNO value of 23.05±15.03. 83.87% of the patients were normal, 14.52% were intermediate and 1.61% were high; There were 58 patients with CVA, the mean FeNO value was 78.36 ± 22.67, of which 1.72% were normal, 8.62% were intermediate, and 89.66% were high; There were 36 patients with UACS, with an average FeNO value of 16.76 ± 7.88, of which 63.89% were normal, 33.33% were intermediate and 2.78% were high; There were 10 patients with EB, with an average FeNO value of 42.75 ± 13.72, of which 10.00% were normal, 50.00% were intermediate and 40.00% were high; There were 5 other patients with an average FeNO value of 15.38 ± 6.62, of which 100.00% were normal, 0.00% were intermediate and 0.00% were high. Compared with PIC, UACS, EB and other groups, the average FeNO value of CVA group was P<0.05, which was statistically significant. Compared with PIC, UACS and other groups, EB group had statistical significance (P<0.05). Compared with UACS and other groups, PIC group had no statistical significance (P>0.05). Compared with UACS and other groups, UACS had no statistical significance (P>0.05). 68 patients in CVA and EB groups were effective after treatment with inhaled hormone budesonide. Among them, 25 patients with CVA (43.10%) improved, 33 patients were cured (56.90%), and the effective rate was 100%. In EB group, 6 cases (43.10%) were improved, 4 cases (40.00%) were cured, and the effective rate was 100%. The total effective rate of the two groups was 100%. The level of FeNO in the two groups decreased significantly, which was significantly different from that before treatment. Conclusion: The detection of exhaled nitric oxide is of great value in the clinical diagnosis and treatment of subacute cough. It is of great significance for the diagnosis of cough variant asthma and eosinophilic bronchitis, and for the treatment of subacute cough.

Key words： Subacute cough Fractional exhaled nitric oxide Cough variant asthma Eosinophilic bronchitis Upper airway cough syndrome Postinfection cough

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	CHU Hui
	ZHANG Jie

Cite this article:

CHU Hui,ZHANG Jie. Significance of Exhaled Nitric Oxide in Clinical Diagnosis and Treatment of Subacute Cough[J]. HeBei Med, 2022, 28(5): 847-852.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.05.031 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I5/847

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