YAG激光对黄褐斑患者抗氧化功能皮肤美容效果及皮肤屏障功能的影响

doi:10.3969/j.issn.1006-6233.2022.05.017

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Abstract Objective: To study the effect and safety of large spot and low-energy Nd:YAG laser in the treatment of chloasma. Methods: Totally 125 patients with chloasma admitted to the hospital were selected between January 2018 and January 2021, and randomly divide into observation group (63 cases) and control group (62 cases) using random number table method. Patients in the control group were treated with hydroquinone cream, and patients in the observation group were treated with large spot low-energy Nd:YAG laser based on the treatment of control group. Therapeutic effects, antioxidant capacity, cosmetic results and skin barrier function in the two groups were compared. Results: After treatment, the total response rate in the observation group was significantly higher than that in the control group (P<0.05). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in the two groups showed no statistically significant difference before and after treatment, and there was no statistically significant difference in the difference value of each indicator before and after treatment (P>0.05). After treatment, MDA was significantly reduced (P<0.05), while SOD and CAT were significantly increased in the two groups (P<0.05). After treatment, skin melanin index (MI) and erythema index (EI) were significantly reduced in the two groups (P<0.05). The difference values of MI and EI before and after treatment in observation group were significantly higher than those in the control group (P<0.05). After treatment, the sebum content and water content of stratum corneum were significantly reduced (P<0.05), while transepidermal water loss (TEWL) was significantly increased in the two groups (P<0.05). There was no significant difference between the two groups in the difference values of sebum content, water content of stratum corneum and TEWL before and after treatment (P>0.05). Conclusion: The large spot low energy Nd:YAG laser combined with hydroquinone cream has better therapeutic and cosmetic skin results than hydroquinone cream only treatment for melasma, and it is safer and does not damage the patient's antioxidant capacity and skin barrier function.

Key words： Chloasma Laser treatment Antioxidant function Cosmetic result Skin barrier function

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	Articles by authors
	YAN Xiaoxue
	WANG Huanhuan

Cite this article:

YAN Xiaoxue,WANG Huanhuan. Effects of YAG Laser on Antioxidant Function Cosmetic Result and Skin Barrier Function in Patients with Chloasma[J]. HeBei Med, 2022, 28(5): 779-783.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.05.017 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I5/779

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