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| Expression and Significance of NF-κB Protein and Apaf-1 Protein in Gastric Cancer |
| YANG Bo, YANG Tao, YANG Dongxia, et al |
| Chengde Central Hospital, Hebei Chengde 067000,China |
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Abstract Objective: To explore the expression and significance of nuclear factor-κB (NF-κB) and apoptotic protease activating factor-1 (Apaf-1) in gastric cancer tissues, and to open up new ideas for the clinical treatment of gastric cancer. Methods: A total of 50 experimental specimens were collected, including gastric cancer tissues and corresponding paracancerous tissues in the same period. The expressions of NF-κB and Apaf-1 proteins were detected by immunohistochemistry SP method, and the relationship between the two and clinical pathological characteristics as well as their correlation were analyzed. Results: The expression level of NF-κB protein in gastric cancer tissues was higher than that of adjacent tissues, while the expression level of Apaf-1 protein was lower than that of adjacent tissues. The protein expression changes of the two proteins were related to the differentiation degree, TNM stage, infiltration depth and lymphatic metastasis (P<0.05). Correlation analysis showed that the expressions of NF-κB protein and Apaf-1 protein in gastric cancer tissues were negatively correlated (rs=-0.36,P<0.05). Conclusion: The abnormal expression of NF-κB and Apaf-1 proteins in gastric cancer tissues may be involved in the occurrence and development of gastric cancer.
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2022, Vol. 28 
