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| Changes in the Levels of Eosinophil Chemokines and Inflammatory Mediators During Acute Exacerbations of Chronic Bronchitis in the Elderly and Their Clinical Significance |
| XIE Mingying, YANG Yuanrui, CAI Lingqin, et al |
| The General Hospital of the Western Area Command, Sichuan Chengdu 610083, China |
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Abstract Objective: To explore the changes and clinical significance of eosinophil chemokines and inflammatory mediators in elderly patients with acute attack of chronic bronchitis. Methods: A total of 186 elderly patients with chronic bronchitis (study group) and 80 healthy elderly people (control group) were selected between August 2020 and September 2021. The levels of eosinophil chemokines and inflammatory mediators in the two groups were tested and compared. Results:The levels of eosinophil chemokines and monocyte chemotactic protein-1 (MCP-1) in study group were higher than those in the control group (P<0.05). The levels of tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) in study group were higher than those in the control group (P<0.05). The levels of eotaxin and MCP-1 in elderly patients with acute attack of chronic bronchitis were higher than those in chronic protracted stage and remission stage (P<0.05). The levels of eosinophil chemokines and MCP-1 in chronic protracted stage were higher than those in remission stage (P<0.05). The levels of TNF-α, hs-CRP and PCT in elderly patients with acute attack of chronic bronchitis were higher than those in chronic protracted stage and remission stage (P<0.05). Conclusion: The detection of Eotaxin, MCP-1, TNF-α, hs-CRP and PCT has important indications in elderly patients with acute attack of chronic bronchitis.
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2022, Vol. 28 
