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| Expression and Correlation Studies of β2-MG MiR-182 BUN in Elderly Chronic Renal Failure |
| SUN Yao, SUN Kun |
| Zibo Central Hospital, Shandong Zibo 255000, China |
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Abstract Objective: To study the expression and correlation of β2 microglobulin (β2-microglobulin, β2-MG), microRNA-182 (miR-182), and blood ureanitrogen (BUN) in elderly chronic renal failure. Methods: Totally 43 patients with chronic renal failure treated from March 2019 to December 2020 were selected as the study group; 43 normal subjects who underwent physical examination in the same period were selected as the control group. Serum miR-182 expression was detected by fluorescence quantitative polymerase chain reaction technique, β2-MG and BUN levels were detected by immunoturbidimetric method, serum CYSC, Scr and RBP levels were detected by enzyme-linked immunosorbent assay, and subject operator characteristics curve (ROC) was used to analyze the diagnostic value of β2-MG, miR-182 and BUN in chronic renal failure in the elderly. Results: The expression levels of β2-MG, miR-182, and BUN in the study group were higher than those in the control group (P<0.05). Correlation analysis showed a positive correlation between β2-MG and miR-182 (r=0.695, P=0.001); between β2-MG and BUN (r=0.733, P=0.001); and between miR-182 and BUN (r=0.778, P=0.001) (P<0.05). The levels of β2-MG, miR-182 and BUN were higher in early stage patients than in non-early stage patients in the study group (P<0.05). The expression levels of β2-MG, miR-182 and BUN were higher in elderly patients with chronic renal failure aged ≥65 years, with oliguria, oedema and large amounts of urine protein (P<0.05). ROC analysis of β2-MG, miR-182 and BUN was less sensitive than the three combined in diagnosing elderly chronic renal failure (P<0.05). Conclusion: β2-MG, miR-182, and BUN are highly expressed in elderly chronic renal failure, and there is a correlation between the three, which has certain clinical value in the diagnosis of elderly chronic renal failure.
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2022, Vol. 28 
