吡格列酮二甲双胍片对初诊多囊卵巢综合征患者性激素胰岛素抵抗及血清炎症指标的影响

doi:10.3969/j.issn.1006-6233.2022.03.033

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Abstract Objective: To investigate the effect of pioglitazone and metformin tablets on sex hormones, insulin resistance, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α ( TNF-α) levels in patients with primary polycystic ovary syndrome (PCOS). Methods: A total of 97 patients with PCOS admitted to our hospital between January 2018 and October 2020 were analyzed retrospectively. According to the treatment regimens, the patients were divided into study group (47 cases) and control group (50 cases). All were treated with ethinylestradiol cyproterone tablets. On this basis, the control group was treated with metformin tablets, and the study group was treated with pioglitazone and metformin tablets, for 3 months. The curative effect, sex hormones, insulin resistance index, serum hs-CRP, IL-6 and TNF-α levels, and quality of life were compared between the two groups. Results: The total effective rate of treatment in the study group was 93.62%, higher than 78.00% in the control group (P<0.05). After treatment, the levels of luteinizing hormone, testosterone, fasting blood glucose, fasting insulin, insulin resistance index, serum hs-CRP, IL-6 and TNF-α were significantly reduced (P<0.05), and the total quality of life scores were significantly increased (P<0.05). Meanwhile, the difference before and after treatment of luteinizing hormone, testosterone, fasting blood glucose, fasting insulin, insulin resistance index, serum hs-CRP, IL-6, TNF-α and the total quality of life score in the study group were higher than those in the control group (P<0.05). Conclusion: Pioglitazone and metformin tablets are more advantageous than monotherapy in the treatment of primary polycystic ovary syndrome, significantly reducing luteinizing hormone and testosterone levels, improving insulin resistance, regulating inflammatory factors and improving quality of life.

Key words： Polycystic ovary syndrome Pioglitazone Metformin Sex hormone Insulin resistance High-sensitivity C-reactive protein Interleukin-6 Tumor necrosis factor-α

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.03.033 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I3/508

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