足月儿缺氧缺血性脑病血清IGF-1 S-100B和GFAP水平检测及其临床意义

doi:10.3969/j.issn.1006-6233.2022.03.06

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Abstract Objective: To detect serum insulin-like growth factor-1 (IGF-1), S-100B protein and glial fibrillary acidic protein (GFAP) levels in term infants with hypoxic-ischemic encephalopathy (HIE), and analyze their clinical significance. Methods: Totally 106 term infants with HIE admitted to the hospital from January 2018 to January 2021 were selected as the observation group. Meanwhile, 30 healthy full-term newborns were made the control group. Subjects in the observation group were divided into survival group (n=91) and death group (n=15) based on improvement after treatment. Serum IGF-1, S-100B and GFAP levels were detected. ROC curve was used to analyze the diagnostic value and prognostic value of serum IGF-1, S-100B and GFAP levels in HIE. Results: Serum IGF-1 level in observation group was lower than that in control group, and the levels of S-100B and GFAP were higher than those in control group (P<0.05). ROC curve analysis showed that the sensitivity of the concurrent diagnosis of HIE was 93.40% with an AUC of 0.886, higher than that of the individual tests(P<0.05). Serum IGF-1 level in survival group was higher than that in death group, and the levels of S-100B and GFAP were lower than those in death group (P<0.05). ROC curve analysis showed that tthe sensitivity of the concurrent diagnosis of HIE with serum IGF-1, S-100B and GFAP levels were 91.50% with an AUC of 0.864, which were higher than those of individual detection (P<0.05). Conclusion: The level of serum IGF-1 is low, and the levels of S-100B and GFAP are high in term infants with HIE. The detection is helpful for early diagnosis and prognosis of HIE.

Key words： Hypoxic-ischemic encephalopathy Term infant Insulin-like growth factor-1 S-100B protein

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.03.06 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I3/379

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