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| Effect of Clopidogrel Combined with Butylbenzene Peptide on Serum Levels of VEGF bFGF Ang-1 and Cognitive Function in Patients with Acute Cerebral Infarction |
| NIU Xiang, WANG Benxiao, BU Hongwei |
| Anhui Wanbei Coal and Electricity Group General Hospital, Anhui Suzhou 234000, China |
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Abstract Objective: To investigate the effect of clopidogrel combined with butylbenzene peptide on serum levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiopoietin-1 (Ang-1) and cognitive function in patients with acute cerebral infarction (ACI). Methods: One hundred and fifty-two patients with ACI admitted to Anhui Wanbei Coal and Electricity Group General Hospital from January 2018 to May 2020 were collected and divided into observation group (n=76) and control group (n=76) with simple random grouping method. Patients in the control group were given routine treatment and clopidogrel. On this basis, patients in observation group were given butylbenzene peptide capsule. The score of National Institutes of Health Stroke Scale (NIHSS), Montreal Cognitive Assessment (MoCA), serum levels of VEGF, bFGF and Ang-1 before and after intervention and the clinical effect were compared between two groups. Results: There were no significant differences in baseline data, NIHSS score, MoCA score, serum levels of VEGF, bFGF and Ang-1 before intervention between the two groups (P>0.05). For intra-group comparison, the NIHSS score at 1 and 3 months after intervention of two groups were apparently lower than those before intervention, and MoCA score, serum levels of VEGF, bFGF and Ang-1 were apparently higher than those before intervention (P<0.05). For inter-group comparison, the NIHSS score in observation group at 1 and 3 months after intervention was apparently lower than that in control group, and the MoCA score, serum levels of VEGF, bFGF and Ang-1 were apparently higher than those in control group (P<0.05). The total efficacy of observation group at 3 months after intervention was apparently higher than that in control group (P<0.05). Conclusion: Clopidogrel combined with butylbenzene peptide could apparently improve the cognitive function of patients with ACI, elevate serum levels of vascular growth related factors such as VEGF, bFGF and Ang-1, whose clinical effect is significant and worthy of clinical application.
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2022, Vol. 28 
