缺血性脑卒中患者静脉溶栓术后早期神经功能恶化危险因素的Meta分析

doi:10.3969/j.issn.1006-6233.2022.12.032

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Abstract Objective: To determine the risk factors of END after intravenous thrombolysis in patients with ischemic stroke based on the meta-analysis. Methods: The evaluation standard of END was that the NIHSS score increased by ≥ 4 points at any time point or the patient died of the disease within 24 hours after admission; the database was searched based on a unified data retrieval strategy from January 2016 to October 2021; Newcastle Ottawa scale and Review Manager 5. 3 were respectively used to assess the quality of the literrature and implement the meta-analysis. Results: 14 papers were included and there were 13 controversial risk factor indexes. TThe combined effect sizes of advanced age, atrial fibrillation, leukocytes, hypertension, and randomized glucose were analyzed to be statistically significant, and the combined effect sizes of stroke of unknown or other cause, stroke history, coronary artery disease, and dyslipidemia in TOAST typing were not statistically significant and the sensitivity analysis results of the above studies were more robust; the sensitivity analysis results of large artery atherosclerotic stroke, small artery occlusive stroke, cardiogenic cerebral infarction, and diabetes mellitus in TOAST typing were less robust. Conclusion: Old age, hypertension, atrial fibrillation, white blood cells and random blood glucose are the risk factors of END after intravenous thrombolysis in patients with ischemic stroke. The sensitivity analysis results of some indicators are poor, which need to be verified by the multi-center and large sample experiments.

Key words： Ischemic stroke(IS) Early neurological deterioration (END) Intravenous thrombolysis Risk factors Meta analysis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.12.032 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I12/2100

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