乳腺癌患者外周血NLR LMR IL-17水平与预后的相关性研究

doi:10.3969/j.issn.1006-6233.2022.12.031

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Abstract Objective: To analyze the correlation between levels of peripheral blood neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and interleukin-17 (IL-17) and survival prognosis in patients with breast cancer. Methods: 120 patients with breast cancer who were treated in the hospital between January 2018 and February 2019 were selected as the research subjects and were included in the breast cancer group, and 106 subjects who underwent breast health examination in the hospital during the same period were selected as healthy controls. The levels of NLR, LMR and IL-17 in peripheral blood were compared between the breast cancer group and the healthy control group at enrollment. The relationship between levels of NLR, LMR and IL-17 and clinicopathological parameters of patients with breast cancer at enrollment was analyzed. The patients in the breast cancer group were followed up at discharge, and the prognosis was statistically analyzed and the predictive value of levels of peripheral blood NLR, LMR and IL-17 on the poor prognosis was analyzed. Results: The levels of NLR and IL-17 in peripheral blood of patients in the breast cancer group were significantly higher than those in the healthy control group (P<0. 05) while the level of peripheral blood LMR was significantly lower than that in the healthy control group (P<0. 05). The levels of peripheral blood NLR. LMR and IL-17 were not related to age, disease type, tumor size, presence or absence of triple-negative breast cancer, ki67 level and assessment of target lesions (P>0. 05), but were related to TNM stage (P<0. 05). The levels of NLR and IL-17 in peripheral blood in the poor prognosis group were significantly higher than those in the good prognosis group (P<0. 05) while the LMR level was significantly lower than that in the good prognosis group (P<0. 05). ROC curve results showed that the combined diagnosis of peripheral blood NLR+LMR+IL-17 had higher predictive efficiency than each indicator alone for poor prognosis of breast cancer, and the predictive value of LMR for poor prognosis of breast cancer had certain limitations (AUC=0. 652). Conclusion: The levels of NLR, LMR and IL-17 in peripheral blood of patients with breast cancer have certain reference value on evaluation of prognosis of patients.

Key words： Breast cancer Neutrophil-to-lymphocyte ratio Lymphocyte-to-monocyte ratio Interleukin-17 Correlation

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.12.031 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I12/2095

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