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| The Effect of GSTP1 Gene on Colorectal Cancer and Its Significance |
| XUAN Bin, WANG Yimin |
| Qinhuangdao First Hospital, Hebei Qinhuangdao 066000, China |
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Abstract Objective: To explore the glutathione S-transferase P-1 (GSTP1) genotype and its clinical significance in patients with colorectal cancer. Methods: The data of 80 patients with colorectal cancer diagnosed in Qinhuangdao First Hospital who agreed to undergo genetic testing were retrospectively selected. According to the GSTP1 gene situation, it is divided into gene mutation group (GSTP1 gene mutation) and gene wild type group (GSTP1 gene wild type). The blood samples and tissue samples of the patients were collected and sent to the Precision Medicine Department of our hospital for GSTP1 expression detection, and test results and the clinical and pathological characteristics of the patients were statistically analyzed. All patients were treated with chemotherapy, and the clinical efficacy, toxic and side effects, and progression-free survival were compared between the two groups. A sum of 18 tissue samples were selected to detect the expression of GSTP1 gene in colorectal cancer and adjacent tissues. Results: The GSTP1 gene detection of 80 patients showed that 35 cases were mutant (gene mutation group) and 45 cases were wild type (gene wild type group). There were no significant differences in the types, histological types, depth of invasion, nerve invasion, vascular tumor thrombus, and lymph node metastasis (P>0.05). The wild-type group (66.67%), with the difference being statistically significant (P<0.05); there was no significant difference in the occurrence of toxic and side effects between the two groups (P>0.05); the follow-up patients in the progression-free survival period gene mutation group [( 4.39±1.24) years] was significantly lower than that of the wild-type group [(6.49±2.15) years], with the difference being statistically significant (P<0.05); the relative expression of GSTP1 mRNA in colorectal cancer tissues was significantly higher than that in adjacent tissues, and the difference was statistically significant (P<0.05). Conclusion: The positive expression rate of GSTP1 gene in colorectal cancer tissues is high, and the chemotherapy effect and prognosis of patients with GSTP1 gene wild type are better than those of gene mutation patients. Clinically, prognostic evaluation and treatment plan selection should be combined with the patient's GSTP1 genotype.
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2022, Vol. 28 
