手术联合<sup>125</sup>I粒子治疗口腔涎腺腺样囊性癌患者可能作用机制分析

doi:10.3969/j.issn.1006-6233.2022.01.07

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Abstract Objective: To study the related growth factors and clinical efficacy of surgery combined ¹²⁵I brachytherapy patients with nts with oral salivary adenoid cystic carcinoma(ACC). Methods: 86 patients with ACC from April 2016 to March 2018 were divided into observation group (41 cases) and control group (39 cases). The control group had surgery, and the observation group had surgery combined with ¹²⁵I brachytherapy. The clinical efficacy were compared between two groups in the three-year follow-up. Before treatment and 6 months after treatment, serum related growth factors were compared between two groups. Results: In the three-year follow-up, the observation group remission rate and control rate were higher than those of the control group (82.93% vs 58.97%, 92.86% vs 74.36%)(χ²=5.598, 4.932, P<0.05). 6 months after therapy, observation group had serum VEGF, bFEG, MMP-9 lower than control group [(238.54±36.25 vs 266.46±32.23)pg/m,(215.42±34.25 vs 276.26±36.12)pg/mL,(493.24±24.36 vs 524.12±30.43)pg/mL](t=3.634, 7.732, 5.023, P<0.05). Conclusion: Surgery combined with ¹²⁵I brachytherapy can improve clinical efficacy of ACC patients, and its mechanism may be related to reducing serum VEGF, BFEG and MMP-9.

Key words： Adenoid cystic carcinoma ¹²⁵I Vascular endothelial growth factor Basic fibroblast growth factor Matrix metalloprteinases-9

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.01.07 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I1/33

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