盐酸羟考酮在腹腔镜下子宫肌瘤剜除术后镇静镇痛中的应用及对患者疼痛介质水平的影响

doi:10.3969/j.issn.1006-6233.2022.01.033

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Abstract Objective: To explore the application effect of oxycodone hydrochloride(OH) in sedation and analgesia after laparoscopic myomectomy, and analyze its influence on pain mediators. Methods: 134 patients who underwent laparoscopic myomectomy in the hospital were selected as the research subjects between May 2019 and May 2021, and were randomly divided into OH1 group (n=45), OH2 Group (n=46) and control group (n=43). All patients were given patient-controlled intravenous analgesia (PCIA) after operation. The OH1 group received PCIA with 20mg of OH and 8mg of ondansetron, the OH2 group received PCIA with 30mg of OH and 8mg of ondansetron, and the control group received PCIA with 50mg of morphine and 8mg of ondansetron. Pain degree, sedative degree, and the levels of pain mediators were compared between the groups. The rescue analgesia rate within 48h after operation, the pressing times of PCA and the occurrence of adverse reactions were recorded. Results: The OH1 group and OH2 group had significantly lower VAS scores and Ramsay scores than the control group at 12h and 24h after operation (P<0.05). The levels of PGE2 and NGF in the OH1 group and the OH2 group at 6h, 12h, and 24h after operation were lower than those in the control group (P<0.05). The rescue analgesia rates in the OH1 group and the OH2 group within 48h after operation were lower than those in the control group, and the pressing times of PCA was less than that in the control group (P<0.05). The incidences of nausea and vomiting, dizziness and drowsiness in the OH2 group during analgesia were higher than those in the OH1 group and the control group (P<0.05). Conclusion: Compared with morphine, OH can achieve better sedative and analgesic effects after laparoscopic myomectomy. In addition, low-dose OH has a lower incidence of adverse reactions and is safer.

Key words： Oxycodone hydrochloride Myomectomy Patient-controlled intravenous analgesia Sedation Pain mediator

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.01.033 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I1/159

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