肺气肿与非小细胞肺癌患者放疗后放射性肺炎的相关影响因素

doi:10.3969/j.issn.1006-6233.2021.08.026

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Abstract Objective: To explore the related factors of emphysema and radiation pneumonia after radiotherapy in patients with non-small cell lung cancer. Methods: From January 2012 to December 2018,166 patients with locally advanced non-small cell lung cancer (NSCLC) were diagnosed by pathology. Patients were divided into RP group (N=40) and NON-RP group (N=126) according to the occurrence of grade 2 radiation pneumonia (RP) 3 months after radiotherapy. The purpose of this study was to explore the related factors of radiation pneumonia after radiotherapy in patients with locally advanced non-small cell lung cancer, and analyze the correlation between emphysema and RP grades. Results: Multivariate Logistic regression analysis showed that emphysema, concurrent radiotherapy and chemotherapy, mean lung dose, CTV volume, and V₅、V₂₀、V₃₀、V₄₀ were related factors for RP after radiotherapy (P<0.05). Spearman correlation showed that emphysema grade was significantly positively correlated with RP grade of NSCLC patients (P<0.05). Conclusion: Emphysema, simultaneous radiotherapy and chemotherapy, mean lung dose, CTV volume, V₅、V₂₀、V₃₀、V₄₀ are related factors for ≥ grade 2 RP after radiotherapy in patients with local advanced stage. Clinical treatment of patients with local advanced stage should fully consider all factors and formulate reasonable radiotherapy plan to reduce the occurrence of RP.

Key words： Non-small cell lung cancer Radiation pneumonia Emphysema Influencing factors Correlation

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	Articles by authors
	MA SongKun
	ZHANG Weilin
	MA Zhiping
	et al

Cite this article:

MA SongKun,ZHANG Weilin,MA Zhiping, et al. Influencing Factors of Emphysema and Radiation Pneumonia After Radiotherapy in Non-Small Cell Lung Cancer Patients[J]. HeBei Med, 2021, 27(8): 1353-1358.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.08.026 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I8/1353

[1] 吕晓伟,陆海军.循环肿瘤细胞与非小细胞肺癌患者血清鳞状细胞癌抗原水平的关系研究[J].河北医学,2018,24(2):290~293.
[2] Ren C ,Ji T ,Liu T ,et al.The risk and predictors for severe radiation pneumonitis in lung cancer patients treated with thoracic reirradiation[J].Radiation Oncology,2018,13(1):69.
[3] 陈火光,王鸿彪,池秀盈,等.不同治疗模式非小细胞肺癌脑转移患者预后及诊断特异性分级预后评估模型和肺肿瘤相关分子分级预后评估模型的临床价值[J].肿瘤研究与临床,2020,32(11):753~759.
[4] 刘爱华,万云鹏,贾玉峰,等.非小细胞肺癌低分割放疗后放射性肺炎的影响因素分析[J].癌症进展,2017,6(15):88~90.
[5] 冯勤付,郑苗丽,曾强.放射性肺炎的诊断和治疗[J].中华放射肿瘤学杂志,2021,30(1):7~10.
[6] 史维雅,杭晶卿,张志勇,等.呼吸气双相HRCT成像对不同COPD表型的定量评估[J].中国临床医学影像杂志,2018,29(5):31~34.
[7] 赖宇,陈凯.放射性肺损伤相关非剂量学因素研究进展[J].西南国防医药,2018,28(1):90~92.
[8] 刘志远,洪梅,肖韡,等.中性粒细胞与淋巴细胞比值对非小细胞肺癌发生放射性肺炎的预测价值[J].中华生物医学工程杂志,2020,26(2):137~143.
[9] 郭雷鸣,丁高峰,徐文才,等.局部晚期非小细胞肺癌患者血清中Ape1/Ref-1,ICAM-1及IL-17A水平与放射性肺炎发生的相关性研究[J].中国肺癌杂志,2018,21(5):383~388.
[10] 王静,贾敬好,宋玉芝,等.局部晚期非小细胞肺癌调强放疗放射性肺炎发生相关因素分析[J].河北医药,2017,4(39):32~36.
[11] 刘志坤,苏景伟,张魏丽,等.107例NSCLC患者放疗后≥2级放射性肺炎预测模型的建立和分析[J].实用肿瘤杂志,2017,32(3):239~243.
[12] 宋慧胜,王馨,汤锐明,等.局部晚期肺癌患者118例放射性肺炎危险因素分析[J].肿瘤学杂志,2019,25(1):46~50.
[13] 苏云涛,朱勇,胡志纲,等.放疗联合化疗治疗局限期小细胞肺癌的临床疗效及预后影响因素研究[J].海南医学,2019,30(11):1385~1387.