海口市原发性痛风患者ABCG2基因rs3114018位点单核苷酸多态性分析

doi:10.3969/j.issn.1006-6233.2021.08.018

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Abstract Objective: To clarify the correlation between ATP binding cassette transporter G2 (ABCG2) rs3114018 and primary gout and provide genetic markers for the early diagnosis of primary gout in Haikou. Methods: A total of 177 patients with gout admitted to our hospital from January 2019 to June 2020 were selected as the experimental group, and 191 healthy controls as the healthy group. Peripheral blood was extracted for detection. High throughput sequencing was used to genotype the rs3114018 locus of ABCG2.The correlation between the genotypes of rs3114018 and the occurrence of primary gout in Haikou was analyzed by statistical method. Results: The frequency of AC type was 35.02% in gout patients and 10.99% in normal population. The frequency of CC type was 35.59% in gout patients and 21.98% in the normal population. The frequency of each genotype in the gout group was statistically different from that in the normal group (P<0.001). The polymorphism of ABCG2 gene rs3114018 was significantly correlated with serum uric acid, blood glucose, creatinine, alanine aminotransferase and glutamate aminotransferase. Compared with AA genotype, the incidence risk of AC carriers increased by 3.273 times, which was 2.642 times after correction, and the incidence risk of CC carriers increased by 3.825 times, which was 3.281 times after correction. Conclusion: The polymorphism of ABCG2 gene rs3114018 is associated with the incidence of primary gout in Haikou, which is a risk factor for the incidence of gout, and is expected to provide a new genetic diagnostic marker for primary gout in Haikou.

Key words： Gout ABCG2 Single nucleotide polymorphism Rs3114018

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.08.018 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I8/1317

[1] Shiozawa A,Szabo SM,Bolzani A,et al.Serum uric acid and the risk of incident and recurrent gout:a systematic review[J].Rheumatol,2017,44(3):388~396.
[2] Yin R,Cao H,Fu T,et al.The rate of adherence to urate-lowering therapy and associated factors in Chinese gout patients:a cross-sectional study[J].Rheumatol Int,2017,37(7):1187~1194.
[3] Wang W,Zhang D,Xu C,et al.Heritability and genome-Wide association analyses of serum uric acid in middle and old-aged Chinese twins[J].Front Endocrinol,2018,9:75.
[4] Nakashima A,Ichida K,Ohkido I,et al.Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients[J].Hum Cell,2020,33:559~568.
[5] Yu KH,Chang PY,Chang SC,et al.A comprehensive analysis of the association of common variants of ABCG2 with gout[J].Sci Rep,2017,7(1):9988.
[6] Fu T,Cao H,Yin R,et al.Associated factors with functional disability and health-related quality of life in Chinese patients with gout:a case-control study[J].BMC Musculoskelet Disord,2017,18(1):429.
[7] Jing J,Ekici AB,Thomos S et al.Genetics of serum urate concentrations and gout in a high-risk population,patients with chronic kidney disease.[J].Sci Rep,2018,8(1):13184.
[8] Singh JA,Bharat A,Khanna D,et al.Health care utilization in patients with gout:a prospective multicenter cohort study[J].BMC Musculoskelet Disord,2017,18(1):233.
[9] Chen CJ,Tseng CC,Yen JH,et al.ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study[J].Sci Rep,2018,8(1):3137.
[10] 王金丹,余玲玲,黄德益,等.ABCG2基因rs2231142位点多态性与浙南地区人群原发性痛风的关系[J].基础医学与临床,2016,36(4):503~507.
[11] 夏燕,陆光辉,黄琼,等.ABCG2基因rs3114018单核苷酸多态性与武陵山地区痛风及高尿酸血症的相关性研究[J].中国免疫学杂志,2018,34(7):1054~1058.