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| Comparison of the Effects of Valsartan and Salcubatrium on Vascular Endothelial Function in Patients with Hypertension and Chronic Heart Failure |
| LI Na, GULIZIREMU Abudumanafu |
| The People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang 830001, China |
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Abstract Objective: To investigate the protective effect of sacubatre and valsartan on vascular endothelial function in patients with hypertension and chronic heart failure. Methods: A total of 159 patients with hypertension and chronic heart failure were simply randomly divided into observation group and control group, 80 cases in the observation group and 79 cases in the control group. The control group was treated with valsartan, and the observation group was treated with sacubitril valsartan, and both groups were treated for 6 months. The brachial artery endothelium-dependent vasodilation (EDD) function, serum nitric oxide (NO), endothelin-1 (ET-1), carotid intima-media thickness, glomerular filtration rate and left ventricular ejection fraction were compared between the two groups before and after treatment. Results: There was no significant difference in EDD, NO and ET-1 between the two groups before treatment (P>0.05). After treatment, compared with the control group, the EDD function of the observation group was significantly increased [(11.78 ± 3.25) vs (10.15 ± 3.17)%, P=0.002], the NO level was significantly increased [(97.24 ± 6.21) vs (82.61 ± 5.35) μmoL / L, P=0.000], and the ET-1 level was significantly decreased [(42.21 ± 7.14) vs (50.42 ± 6.36) ng / L, P=0.000]. There was no significant difference in carotid intima-media thickness, glomerular filtration rate and left ventricular ejection fraction between the two groups before and after treatment (P>0.05). Conclusion: Sacubitril valsartan have protective effect on vascular endothelial function in patients with hypertension and chronic heart failure.
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2021, Vol. 27 
