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| Correlation Between Heart Rate Variability and PCT in Patients with Kawasaki Disease and Its Value in Predicting Coronary Artery Injury |
| LUO Jie, et al |
| Suzhou Science and Technology Town Hospital, Nanjing Medical University, Jiangsu Suzhou 215153, China |
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Abstract Objective: To explore the correlation between heart rate variability (HRV) and PCT in children with Kawasaki disease and its value in predicting coronary artery injury. Methods: 86 cases of children with Kawasaki disease diagnosed in our hospital from January 2017 to June 2019 were retrospectively selected, including 46 male patients and 40 female patients, aged 1 to 5 years, average age 2.53 ± 1.14 years old. All children underwent echocardiography before treatment. According to whether coronary artery damage occurred, they were divided into group A (coronary artery damage group, 42 cases) and group B (non-coronary artery damage group, 44 cases). Healthy children served as a control group. HRV indicators (time domain indicators, frequency domain indicators) were tested for children in each group, and the serum PCT levels of children in each group were detected by immunofluorescence chromatography. The three groups of children's HRV time domain indicators and frequency domain indicators were observed and compared, and the PCT levels of children in each group were compared. Results: The results showed that children with Kawasaki disease compared with normal children in the control group had statistically significant differences in HRV time-domain and frequency-domain indicators (P<0.05), and children in group A had significantly lower HRV indicators than group B. The difference was statistically significant (P<0.05). The serum PCT levels of children in groups A and B were significantly higher than those in the control group, and the serum PCT levels (2.85 ± 1.28 ng / ml) in group A were significantly higher than those in group B (1.26 ± 0.93 ng / ml) (P<0.05). Conclusion: There is a good correlation between heart rate variability (HRV) and serum PCT levels in children with Kawasaki disease. At the same time, the above two indicators can more accurately predict whether children will have coronary artery injury. It has good diagnostic value and is suitable for the early clinical diagnosis of Kawasaki disease and Kawasaki disease combined with coronary artery injury, so as to provide a basis for the timely treatment of children. It is worthy of clinical promotion.
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2021, Vol. 27 
