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| Correlation Analysis of Blood Lipid Ratio Chemerin Level and Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome |
| ZHAO Yuanyuan, DING Zhenjiang, TIAN Yanan, et al |
| The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the relationship between the serum lipid ratio and Chemerin level in patients with acute coronary syndrome (ACS) and the severity of coronary artery disease, to evaluate the clinical predictive value of the ratio of serum lipids and Chemerin level in patients with acute coronary syndrome (ACS). Methods: 230 patients who had done the coronary angiography in our hospital from July 2019 to January 2020 were selected that met the inclusion criteria, and their medical records and clinical examination data were collected and divided into ACS group (164 cases) and control group (66 cases). ACS group included unstable angina pectoris group (87 cases) and acute myocardial infarction group (77 cases). At the same time, Gensini score was divided into three groups: low group, medium group and high group. The differences of blood lipid ratio and Chemerin level among the groups and the correlation with the severity of coronary artery disease were analyzed. Results: Comprehensive analysis showed that the levels of TC / HDL-C, TG / HDL-C, non-HDL-C / HDL-C, LDL-C / HDL-C, LCI and Chemerin in ACS group were significantly higher than those in control group, and they were positively correlated with the severity of coronary artery disease (P<0.01), and Chemerin level was also positively correlated with TC / HDL-C, LDL-C / HDL-C, non-HDL-C / HDL-C (P<0.01). By establishing binary logistic regression model, Chemerin was found to be an independent risk factor for ACS (or = 1.03, P<0.01). The cut-off value of Chemerin in predicting ACS was 619.00ng/ml and the area under the ROC curve was 0.716( P<0.001,95%CI:0.649～0.783). Conclusion: The serum lipid ratio and Chemerin level in patients with acute coronary syndrome are significantly higher than those in the control group, and they are positively correlated with Gensini score. Meanwhile, the increase of Chemerin level can be used as an independent risk factor to predict ACS, and has high predictive value for ACS.
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2021, Vol. 27 
