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| Correlation Between MicroRNAs of Serum and Endothelial Cell Function in Elderly Patients with Acute Myocardial Infarction and Heart Failure |
| GULIZIREMU Abudumanafu, LI Na |
| The People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang 830001, China |
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Abstract Objective: To investigate the correlation between serum microRNAs and vascular endothelial cell function in elderly patients with acute myocardial infarction and heart failure. Methods: From January 2018 to December 2020, 56 elderly patients with acute myocardial infarction and heart failure in our hospital were retrospectively collected as an observation group, while 93 patients with simple myocardial infarction in our hospital were collected as a control group. The serum levels of miRNA-145, miRNA-19b and miRNA-96 were detected, and the correlation between serum miRNA-145, miRNA-19b and miRNA-96 and vascular endothelial cell function were analyzed. Results: Compared with the control group, miRNA-145, miRNA-19b and miRNA-96 in the observation group were significantly increased (1.76 ± 0.32 vs 1.04 ± 0.31, P<0.001, 1.52 ± 0.44 vs 1.08 ± 0.37, P<0.001, 2.76 ± 0.54 vs 1.43 ± 0.62, P<0.001, respectively). Pearson linear correlation showed that miRNA-145, miRNA-19b and miRNA-96 were negatively correlated with FMD, NO and LVEF, and positively correlated with ET-1 and NT-Pro BNP (P<0.05). Conclusion: The miRNA-145, miRNA-19b and miRNA-96 are significantly increased in patients with acute myocardial infarction and heart failure, and are related to the function of vascular endothelial cells.
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2021, Vol. 27 
