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| Clinical Efficacy and Mechanism of Hulisan Capsule combined Nail Internal Fixation on Garden Type Ⅲ and Ⅳ Femoral Neck Fractures in Young and Middle-aged Patients |
| WANG Rongsheng, HAN Xue, WANG Jing, et al |
| The Central Hospital of Chengde, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the clinical curative effect and the mechanism of Hulisan capsule combined nail internal fixation on GardenⅢ, Ⅳyoung and middle-aged femoral neck fracture.Methods: 130 patients with femoral neck fractures were divided into control group and combined treatment group. Patients in the control group were treated with nail internal fixation, and patients in the combined treatment group were treated with Hulisan capsule after nail internal fixation. Fracture healing, femoral head necrosis rate, incidence of femoral neck shortening, serum oxidative stress and inflammatory factors concentration and hip joint function of patients in the two groups were observed. Results: After surgery, the patients received Hulisan capsule combined nail internal fixation showed the fracture healing time was significantly shorter (P<0.01) and fracture healing rate increased significantly (P<0.05), and 6 months after operation, femoral head necrosis rate and incidence of femoral neck shortening significantly decreased (P<0.05), serum oxidative stress indicators increased significantly(P<0.01), serum inflammatory factors indicators decreased significantly(P<0.01),Harris hip score increased significantly (P<0.01), and Harris hip function evaluation effect of excellent and good rate increased significantly (P<0.05).Conclusion: Hulisan capsule combined nail internal fixation treatment significantly improved fracture healing and femoral head necrosis rate, improve the patient's hip joint function of GardenⅢ, Ⅳ young and middle-aged femoral neck fracture. Its mechanism of action may be achieved through anti-oxidative stress and anti-inflammation.
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2021, Vol. 27 
