|
|
Changes of Serum MBL Masp-2 and DKK-1 Levels in Patients with Rheumatoid Arthritis and Their Correlation with Prognosis |
ZANG Xuelian, JU Yanling, ZHAO Xu |
Jinzhou Central Hospital, Liaoning Jinzhou 121000, China |
|
|
Abstract Objective: To study the changes of levels of serum mannose-binding lectin (MBL), MBL-associated serine protease-2 (MASP-2) and Dickkopf-1 protein (DKK-1) in patients with rheumatoid arthritis (RA) and their correlation with prognosis of patients. Methods: 194 RA patients and 102 health examiners in our hospital from August 2017 to August 2020 were selected as the study group and the control group. Serum MBL, masp-2 and DKK-1 levels were detected at admission. According to 28 joint disease activity scores (DAS28), the patients were divided into mild group (n = 83), moderate group (n = 62) and severe group (n = 49). According to the guidelines, RA patients were given standard treatment. According to the efficacy, the patients were divided into standard group (n = 129) and standard group (n = 65), The serum levels of MBL, masp-2 and DKK-1 were compared in each group, and their influence on DAS28 score and predictive value for curative effect were analyzed. Results: The levels of serum MBL and MASP-2 in study group were lower than those in control group, while the level of serum DKK-1 was higher than that in control group. The levels of serum MBL and MASP-2 in mild, moderate and severe groups were gradually decreased, while the level of serum DKK-1 and DAS28 score were gradually increased. The levels of serum MBL and MASP-2 in standard group were higher than those in non-standard group, while the level of serum DKK-1 was lower than that in non-standard group (P<0.05). Multivariate linear regression analysis showed that the levels of serum MBL and MASP-2 were important factors affecting the DAS28 score (P<0.05). Serum MBL and MASP-2 levels were closely related to the treatment effect of RA, and logistics regression model of substandard RA treatment was shown as Y=12.573-0.722× serum MBL-0.090× serum MASP-2+0.792× serum DKK-1. The AUC values of serum MBL, MASP-2, DKK-1 and the combined detection of the three in predicting the efficacy of RA were 0.896, 0.825, 0.693 and 0.958 respectively, and the sensitivities were 72.09%, 67.44%, 80.62% and 89.15%, and the specificities were 90.77%, 81.54%, 52.31% and 90.77%. Conclusion: The levels of MBL and masp-2 in serum of RA patients were significantly decreased, while the level of DKK-1 in serum was significantly increased, which was closely related to the changes of the disease, and could provide reference information for the evaluation of curative effect and prognosis.
|
|
|
|
|
[1] Heidari B,Hajian-Tilaki K,Babaei M.Vitamin D deficiency and rheumatoid arthritis: epidemiological,immunological,clinical and therapeutic aspects[J].Mediterr Rheumatol,2019,30(2):94~102. [2] Lazzerini PE,Capecchi PL,Laghi-Pasini F.Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis[J].Eur Heart,2017,38(22):1717~1727. [3] 孙垚,高蕾,潘丽,等.类风湿关节炎患者躯体功能受限影响因素研究[J].现代预防医学,2019,46(5):955~960. [4] 陈思,马宝良,曹明强,等.类风湿关节炎患者血清MBL、MASP-2、HsCRP与C3水平的相关性[J].南方医科大学学报,2016,36(10):1340~1344,1356. [5] Seror R,Boudaoud S,Pavy S,et al.Increased dickkopf-1 in recent-onset rheumatoid arthritis is a new biomarker of structural severity.Data from the ESPOIR Cohort[J].Sci Rep,2016,6:18421. [6] 中华医学会风湿病学分会.类风湿关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(4):265~270. [7] 廖黔华,郭林凯,罗十之,等.肾虚型类风湿关节炎与B淋巴细胞人免疫球蛋白GFc段受体Ⅱ b的相关性研究[J].中国中西医结合杂志,2013,33(9):1203~1207. [8] 宋岩奇,赵文,宋敏,等.类风湿病患者髋关节受累骨肌系统影像学表现与临床特点的相关性[J].中国医药导报,2018,15(4):117~119,125. [9] Singh SS,Cheung RC,Wong JH,et al.Mannose binding lectin: a potential biomarker for many human diseases[J].Curr Med Chem,2016,23(33):3847~3860. [10] 蔡鑫,唐芳,马武开,等.Wnt/β-catenin拮抗剂DKK-1在强直性脊柱炎中的研究进展[J].风湿病与关节炎,2019,8(11):67~70,74. [11] Chae WJ,Ehrlich AK,Chan PY,et al.The wnt antagonist dickkopf-1 promotes pathological type 2 cell-mediated inflammation[J].Immunity,2016,44(2):246~258. |
|
|
|