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| Clinical Value of Combined Examination of Serum β-HCG PCT and CRP and Secretion GBS in Predicting Chorioamnionitis and Neonatal Infection in Pregnant Women with Premature Rupture of Membranes |
| GAO Yanjie, GONG Chuntao, WANG Haixia, et al |
| Aikang Hospital of Huangshi, Hubei Huangshi 435000, China |
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Abstract Objective: To investigate the clinical value of combined examination of serum β-chorionic gonadotropin (β-HCG), procalcitonin (PCT) and C-reactive protein (CRP) and secretion group B streptococcus (GBS) in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes (PROM). Methods: From September 2019 to September 2020, 300 pregnant women were selected, including 100 cases with PROM of term (tPROM group), 100 cases with preterm PROM (PPROM), and 100 pregnant women without PROM undergoing termination of pregnancy by cesarean section (control group). Maternal serum β-HCG, PCT and CRP levels and GBS positive rate, neonatal cord blood PCT and CRP were detected. Results: Serum β-HCG, PCT and CRP levels and GBS positive rate in the PPROM group were higher than those in the tPROM group and control group (P<0.05). Besides, serum β-HCG, PCT and CRP levels and GBS positive rate in the chorioamnionitis group were higher than those in the non-chorioamnionitis group (P<0.05).ROC curve analysis showed that the sensitivity and AUC of serum β-HCG, PCT and CRP levels in tandem detection of pregnant women with premature rupture of membranes complicated with chorionic amnitis were higher than those of single detection(P<0.05). Cord blood PCT and CRP levels in sepsis group were higher than those in the neonatal pneumonia group, non-infection group and control group (P<0.05). Conclusion: Pregnant women with PROM have elevated serum β-HCG, PCT and CRP levels and GBS positive rate. Combination of the four has higher value in predicting chorioamnionitis. Cord blood PCT and CRP levels can help early diagnosis of neonatal infection.
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2021, Vol. 27 
