Myosin1H基因多态性与蒙古族骨性下颌后缩易感性的关系

doi:10.3969/j.issn.1006-6233.2021.06.05

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Abstract Objective: To analyze the correlation between polymorphism of type I myosin (myosin1H) gene and the susceptibility of skeletal mandibular retrusion (MR) in Mongolian. Methods: A total of 61 patients with skeletal type II malocclusion (mainly on MR) who were treated in stomatology department of the hospital were made the observation group, while another 61 patients with skeletal type I malocclusion were made the control group. All were Mongolian cases in Inner Mongolia. The distribution of Myosin1H gene polymorphisms at rs11611277 and rs3825393 loci was detected by polymerase chain reaction-restriction fragments length polymorphism (PCR-RELP). The correlation between Myosin1H gene polymorphism and the susceptibility of skeletal MR was analyzed. Results: The genotype carrying AG and frequency of A allele in observation group were 60.66% and 38.52%, higher than those in control group (24.59%, 23.77%) (P<0.05). In observation group, SNB angle and Z angle in patients carrying AG genotype at rs3825393 locus wee (81.49±1.73)° and (62.25±4.75)°, lower than those carrying GG genotype [(82.18±1.57)°, (82.16±1.95)°] and AA genotype [(72.14±5.11)° , (73.52±6.34)°] (P<0.05), while ANB angle [(5.91±0.75)°] was higher than those carrying GG genotype [(4.21±1.45)°] and AA genotype [(4.19±0.65)°] (P<0.05). Taking GG genotype as control group, carrying AG genotype of Myosin1H gene at rs3825393 could increase the susceptibility to MR by 2.571 times (P<0.05). Conclusion: G→A mutation of Myosin1H gene at rs3825393 locus is related to the susceptibility of MR in Mongolian. The risk of susceptibility to MR is higher in patients with AG genotype at the locus.

Key words： Type I myosin Skeletal mandibular retrusion Skeletal type II malocclusion Gene polymorphism Susceptibility

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	LI Xiaohui
	CHENG Shuyu
	BA Gena
	et al

Cite this article:

LI Xiaohui,CHENG Shuyu,BA Gena, et al. The Correlation Between Myosin1H Gene Polymorphism and the Susceptibility of Skeletal Mandibular Retrusion in Mongolian[J]. HeBei Med, 2021, 27(6): 901-905.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.06.05 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I6/901

[1] Cai Y,Ni Z,Chen W,et al.The ADAMTS9 gene is associated with mandibular retrusion in a Chinese population[J].Gene,2020,749(30):144701.
[2] 王璐瑶,孙博宁,张继东,等.OSAHS患者颅面上气道形态特征及OSAHS与CAD相关性的研究[J].实用口腔医学杂志,2020,36(2):321~325.
[3] 程慧娜,周青.下颌骨特发性髁突吸收的研究进展[J].口腔医学研究,2019,35(5):427~429.
[4] 于淼,杨婉琪,葛悦,等.骨性Ⅱ类高角错合的垂直向控制研究进展[J].中国实验诊断学,2020,24(5):880~882.
[5] Ozbilek S,Gungor A Y,Celik S.Effects of skeletally anchored class II elastics:a pilot study and new approach for treating class II malocclusion[J].Angle Orthod,2017,87(4):505~512.
[6] 曾祥龙.现代口腔正畸学诊疗手册[M].北京:北京医科大学出版社,2000.309~310.
[7] 尹倩.Myosin 1H基因多态性与骨性下颌后缩相关性的初步研究[D].山西:山西医科大学,2018.
[8] 黄智梅.安氏Ⅱ类错颌畸形的形成原因及矫治机制新进展[D].湖北:华中科技大学,2016.
[9] 高盟,刘冬梅,程锦,等.骨性Ⅱ类错合拔牙矫治前后下颌牙弓与基骨形态的变化[J].中华医学美学美容杂志,2018,24(3):188~191.
[10] 姜玲玲,曹玉慧,刘占帅,等.哈尔滨市12087名学龄儿童错合畸形患病率及影响因素研究[J].口腔医学,2019,39(10):931~935.
[11] 李响,姜艳,王鸥,等.LMNA基因突变致下颌骨锁骨发育不全的临床特征[J].中华骨质疏松和骨矿盐疾病杂志,2019,12(4):347~355.
[12] Aksakalli S,Calik B,Kara B,et al.Accelerated tooth movement with piezocision and its periodontal-transversal effects in patients with Class II malocclusion[J].Angle Orthod,2016,86(1):59-65.
[13] 杨文英,张文丽,罗应伟.不平衡咀嚼肌力作用下髁突软骨下骨中OPG/RANKL的表达[J].昆明医科大学学报,2017,38(2):23~27.
[14] Zattelman L,Regev R,Usaj M,et al.N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.[J].Biol Chem,2017,292(43):17804~17818.
[15] Arun R M,Lakkakula B V K S,Chitharanjan A B.Role of myosin 1H gene polymorphisms in mandibular retrognathism[J].Am Orthod Dentofacial Orthop,2016,149(5):699~704.