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| An Analysis of the Effect of Maternal-Infant Blood l Group Incompatibility on Neonatal Hemolysis |
| ZHAO Jun, ZHANG Lei, et al |
| The Third Hospital of Hebei Medical University, Hebei Shijiazhuang 050082, China |
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Abstract Objective: To investigate the high distribution of antibody titers in maternal-fetal ABO blood type incompatibility and its effect on the newborn with ABO blood type incompatible hemolytic disease. Methods: A retrospective analysis of 760 type O Rh-negative parturients (whose husbands are not type O Rh-negative) and their newborns is made to discuss the high distribution of antibody titers and the effect on hemolysis of newborns. Results: Among 760 pregnant women with ABO incompatibility, the titer increases with the increasing of gestational time and gestational age, and the difference is statistically significant. These pregnant women are sub-grouped according to their husbands' ABO blood type, and there is no significant difference in antibody titers between groups. With the increasing of antibody titer, the incidence of hemolytic disease in newborns is on the rise. Conclusion: Dynamic monitoring of maternal antibody titers during pregnancy is significant to reducing neonatal hemolytic disease caused by maternal-fetal ABO blood type incompatibility and can improve the quality of the birth population.
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[1] 曹泽毅.中华妇产科学[M].北京:人民卫生出版社,1999.647~649.
[2] 范玲.妊娠期ABO血型不合溶血病的防治[J].中国实用妇科与产科杂志,2010,12(6):475~477.
[3] 王蔚军,付一元,郭勇,等.母儿ABO血型不合诊治的探讨[J].中国优生与遗传杂志,2010,18(5):64~65.
[4] 夏爱军,樊文昕,张献清,等.IgG亚型检测对高效价抗体孕妇的临床意义[J].中国输血杂志,2014,27(2):2.
[5] 何华庆,李国良,韩玲,等.抗-M致献血ABO者血型鉴定正反定型不符分析[J].实验与检验医学,2015,33(3):283~284.
[6] 周佩珊,黄群,许少榆.母胎ABO血型不合孕妇IgG抗体效价与新生儿溶血病的关系[J].海南医学,2015,26(5):667~669.
[7] Komaru Y,Higuchi T,Koyamada R,et al.Primary sjogren syndrome presenting with hemolytic anemia and pure red cell aplasia follow-ing delivery due to coombs-negative autoimmune hemolytic anemiaand hemophagocytosis [J].Internal Medicine (Tokyo,Japan),2012,52(20):2343~2346.
[8] 陈诚,常青,王延洲,等.母胎ABO血型不合孕妇抗体效价与围产儿溶血病的关系[J].中华围产医学杂志,2013,16(3):119~122.
[9] Ru KA,Mai DM,Re BM,et al.The clinical analysis of risk fac-tors about ABO type hemolytic disease of the new-born [J].Prog-ress in Modern Biomedicine,2012,12(26):2984~2989.
[10] 刘燕,韩光辉.孕妇IgG抗体效价与新生儿溶血发病率的关系[J].中国妇幼健康研究,2014,25(1):77~78.
[11] 张丹,申晓环,张静蕊.孕妇IgG抗A或抗B效价与ABO系统新生儿溶血病的关系[J].临床军医杂志,2013,41(11):1182~1184
[12] 房笃智,姚伟.O型血孕妇血清IgG抗体效价与新生儿ABO溶血的关系[J].中国优生与遗传杂志,2015,23(11):76~79. |
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2021, Vol. 27 
