|
|
|
| Influence of Operation Combined with Corneal Limbal Stem Cell Autograft Transplantation on Visual Quality Corneal Diopter and Tear Film Function in Pterygium Patients |
| HUANG liumeng, XIE Shunong |
| The 909 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Fujian Zhangzhou 363000, China |
|
|
|
|
Abstract Objective: To treat pterygium patients with pterygium excision combined with corneal limbal stem cell autograft transplantation, and to explore the effects on visual quality, corneal diopter and tear film function. Methods: A total of 120 pterygium patients who were treated in the hospital from September 2017 to December 2019 were enrolled as the research objects. They were divided into study group (n=60) and control group (n=60) by random number table method. The control group was treated with pterygium excision, while study group was treated with corneal limbal stem cell autograft transplantation after pterygium excision. Their effects on visual quality, corneal diopter and tear film function were analyzed. Results: After surgery, SR and IMTFcutoff were significantly increased, while TF-OS was decreased in both groups. SR and IMTFcutoff in study group were significantly higher than those in control group, while TF-OS was lower than that in control group (P<0.05). After surgery, UCVA, corneal vertical curvature and horizontal curvature were significantly increased, while CAD was decreased in both groups. UCVA, corneal vertical curvature and horizontal curvature in study group were significantly lower than those in control group, while CAD was higher than that in control group (P<0.05). After surgery, BUT and SIT were significantly increased in both groups, which were significantly higher in study group than control group (P<0.05). After surgery, scores of OSDI and CFS were significantly decreased in both groups, which were lower in study group than control group (P<0.05). After surgery, incidence of complications and recurrence rate in study group were 1.67% and 5.00%, which were significantly lower than those in control group (13.33%, 18.33%) (P<0.05). Conclusion: Pterygium excision combined with corneal limbal stem cell autograft transplantation in the treatment of pterygium can significantly improve corneal diopter, tear film function and visual quality, which can reduce damage to eye epithelial cells and postoperative recurrence rate, with better prognosis.
|
|
|
|
|
|
[1] 庄博,李秀红,王圣识,等.自体角膜缘干细胞移植对翼状胬肉患者视觉质量及泪膜功能的影响[J].解剖学报,2018,49(6):720~723.
[2] Gonzalez-Gil A,Picazo RA,de Bruyn P,et al.Corticoadrenal and cardiorespiratory responses to administration of propofol Combined with dexmedetomidine or ketamine in rabbits[J].Am Assoc Lab Anim Sci,2018,57(3) :278~281.
[3] 胥婷婷,朱华丽,刘蓓,等.高原地区翼状胬肉患者术后复发的危险因素分析及预测指数模型构建[J].实用医院临床杂志,2019,16(5):57~60.
[4] 亚洲干眼协会中国分会,海峡两岸医药交流协会眼科专业委员会眼表与泪液病学组.我国翼状胬肉围手术期用药专家共识(2017年)[J].中华眼科杂志,2017,53(9):653~656.
[5] 钱丽君,周桂贞,朱苏宁,等.揿针对翼状胬肉切除术后患者疼痛及泪膜稳定性的影响[J].中国针灸,2019,39(3):267~270.
[6] 阴洁,陈耀祖,辛延峰,等.两种手术方式治疗翼状胬肉的疗效及对泪膜功能的影响[J].浙江临床医学,2019,21(12):1670~1672.
[7] 海鸥,刘芳,李鹏,等.不同翼状胬肉切除术式对患者术后泪膜功能的影响[J].国际眼科杂志,2019,19(8):1439~1441.
[8] 明敏,吕慧.翼状胬肉切除联合不同移植术治疗对术后眼表修复影响[J].创伤与急危重病医学,2019,7(1):52~53,56.
[9] 麻利明,李波.老年翼状胬肉患者行翼状胬肉切除联合角膜缘干细胞移植的疗效及对泪膜功能的影响[J].河北医学,2019,25(7):1105~1108. |
|
|
|
2021, Vol. 27 
