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| The Role of LFA-1 in the Neutrophilic Inflammatory Response of Chronic Obstructive Pulmonary Disease |
| LIN Yuting, LI Weijian, HUANG Peikai |
| Huizhou Central People's Hospital, Guangdong Huizhou 516000, China |
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Abstract Objective: To investigate the expression of lymphocyte function-associated antigen-1 (LFA-1) in chronic obstructive pulmonary disease (COPD) neutrophilic inflammation and its clinical significance. Methods: A total of 40 patients with acute exacerbation of COPD (AECOPD) who were in the Huizhou Central People's Hospital from January 2019 to December 2020 were made the AECOPD group, another 40 patients with stable COPD were made the stable COPD group, and 20 healthy volunteers served as a control group. Comparison was conducted among groups on LFA-1 with neutrophilic factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), inflammatory Protein thymic stromal lymphopoietin (TSLP), high mobility group protein 1 (HMGB1)] and their correlations, and different clinical characteristics of LFA-1 levels and their independent influencing factors were analyzed. Results: Comparison of the levels of LFA-1, TNF-α, IL-6, IL-8, TSLP and HMGB1 in the three groups: AECOPD group>COPD stable>control group, all were statistically significant (P<0.05). According to Pearson analysis, LFA-1 is not correlated with TNF-α, TSLP, HMGB1 (P>0.05), and LFA-1 is positively correlated with IL-6, IL-8 (P<0.05). According to univariate analysis, smoking, chronic obstructive pulmonary disease assessment test (CAT) score, modified version of British Medical Research Council respiratory questionnaire (mMRC) classification, Global Initiative for Chronic Obstructive Lung Diseas (GOLD) classification are the factors that affect LFA-1 levels (P<0.05); After multiple linear regression analysis, smoking, CAT score, mMRC classification, and GOLD are independent risk factors that affect LFA-1 levels(P<0.05). Conclusion: COPD patients have high expression of LFA-1 and neutrophilic factors, and AECOPD is higher than that of patients with stable COPD. COPD patients LFA-1 and LFA-1 are related to neutrophilic factors. Smoking, CAT score ≥10, mMRC grade ≥ 2, GOLD grade ≥2 are the reasons for the high level of LFA-1.
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2021, Vol. 27 
