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| Expression Value of ADMA and DDAH2 in Early Onset Severe Preeclampsia |
| WANG Yu, ZHOU Dujuan, HUANG Yan, et al |
| Suzhou Hospital Affiliated to Anhui Medical University, Anhui Suzhou 234000, China |
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Abstract Objective: To observe the expression levels of asymmetric dimethylarginine (ADMA) and dimethylarginine dimethylamine hydrolase (DDAH) in serum and placenta of patients with severe preeclampsia, and the correlation between ADMA and DDAH. Methods: 62 patients with severe preeclampsia admitted to Suzhou Hospital Affiliated to Anhui Medical University from January 2017 to October 2020 were prospectively selected as the research subjects, including 32 cases of early-onset severe preeclampsia and 30 cases of late-onset severe preeclampsia. 30 healthy pregnant women in our hospital during the same period were selected as the control group. The serum ADMA and ddah2 expression levels and placental ADMA and ddah2 expression levels of the three groups were detected. The correlation between the expression of ADMA and ddah2 in serum was analyzed. Results: The level of serum ADMA in early-onset severe preeclampsia group was significantly higher than that in late-onset severe preeclampsia group and control group, and the level of serum ddah2 was lower than that in late-onset severe preeclampsia group and control group, with statistical significance (P<0.05); the positive expression rate of ADMA in placental tissue in early-onset severe preeclampsia group (93.75%) was significantly higher than that in late-onset severe preeclampsia group (66.67%) and control group (P<0.05) .The positive expression rate of ddah2 in placenta (37.50%) was significantly lower than that in late-onset severe preeclampsia group (66.67%) and control group (80.00%) (P<0.05). Pearson correlation coefficient analysis showed that serum ADMA level was negatively correlated with ddah2 in early-onset and late-onset severe preeclampsia (r=-0.71,-0.77,P<0.05). Conclusion: Compared with normal pregnant women and late-onset preeclampsia pregnant women, early-onset severe preeclampsia patients showed high expression of ADMA and low expression of ddah2. Both of them were involved in the formation and development of early-onset severe preeclampsia, which should be paid attention to.
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2021, Vol. 27 
