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| Effect of Protein Iron Succinate Combined with Vitamin C on Reticulocyte and Crythrocyte Parameters in Pregnant Women with Iron Deficiency Anemia |
| CHEN Lin, ZENG Yuhong, XIAO Yin, et al |
| Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Hainan Haikou 570208, China |
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Abstract Objective: To explore the curative effect of iron-protein succinylate combined with vitamin C in the treatment of pregnant women with pregnancy complicating iron deficiency anemia (IDA) and its influence on reticulocytes and red blood cell parameters. Methods: Totally 147 pregnant women with pregnancy complicating iron deficiency anaemia who were treated in our hospital were selected as the research subjects, and they were divided into combined group and control group according to the Simple random grouping. Control group (n=73) was treated with ferrous fumarate tablets, and combined group (n=74) was given iron-protein succinylate and vitamin C. The clinical curative effect, reticulocytes [absolute reticulocyte value (RET), immature reticulocyte fraction (IRF), corpuscular hemoglobin concentration mean of reticulocyte (CHCMr)], red blood cell parameters [red blood cell count (RBC), mean corpuscular volume (MCV), hemoglobin (Hb), mean corpuscular hemoglobin (MCH)], iron metabolism [serum iron (SI), serum ferritin (SF), transferrin receptor (sTFr), serum total iron binding capacity (TIBC)], adverse reactions and perinatal outcomes were compared between the two groups. Results: After 6 weeks of treatment, the total clinical effective rate was 95.95% in combined group and was 86.30% in control group (P<0.05). The levels of RET and CHCMr in the peripheral blood of the two groups were significantly increased (P<0.05) while the level of IRF was significantly reduced (P<0.05), and the difference in the amplitude of change between the two groups was statistically significant after treatment (P<0.05). The levels of peripheral blood RBC, MCV, Hb, and MCH in the two groups were significantly increased (P<0.05), and the levels of serum SI and SF were significantly increased (P<0.05) while the levels of sTFr and TIBC were significantly reduced, and the difference in the amplitude of change between the two groups was statistically significants after treatment (P<0.05). During treatment, the total incidence rate of adverse reactions was 5.41% in combined group and was 9.59% in control group (P>0.05). At follow-up after treatment, the premature birth rate and incidence rate of maternal-infant adverse events were 4.05% and 5.41% in combined group and were 6.85% and 10.96% in control group (P>0.05). Conclusion: Iron-protein succinylate combined withvitamin C in the treatment of pregnancy complicating iron deficiency anemia can significantly improve the therapeutic effect, improve the development of red blood cells, and promote iron metabolism, with fewer adverse drug reactions and perinatal adverse events.
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2021, Vol. 27 
