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| Curative Effect of Holmium Laser Enucleation of the Prostate in the Treatment of Large-Volume Prostate and Its Influence on Urodynamics Serum T-PSA and F-PSA Levels |
| HUANG Wei, HAN Junling, SHEN Hongfeng |
| The 928 Hospital of Joint Service Logistic Support Forces of the People's Liberation Army, Hainan Haikou 570206, China |
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Abstract Objective: To study the curative effect of holmium laser enucleation of the prostate (HOLEP) in the treatment of large-volume prostate, and its influence on urodynamics, serum total prostate specific antigen (T-PSA) and free prostate specific antigen (F-PSA) levels. Methods: A total of 107 male patients with benign prostate hyperplasia (BPH) treated in the hospital between January 2018 and December 2020 were enrolled in and randomly divided into control group (53 cases) and observation group (54 cases). The control group was treated with transurethral resection prostate (TURP), while observation group was treated with HOLEP. The surgical indexes, serum T-PSA and F-PSA levels, urodynamics, sexual function and the incidence of postoperative complications in the two groups were compared. Results: Compared with the control group, the observation group had significantly longer operation time, bladder irrigation time, catheter indwelling time and hospital stay, and significantly less blood loss (P<0.05). At 3 months after surgery, the observation group had significantly larger urine flow and bladder volume, and significantly less residual urine than the control group (P<0.05). At 1 month after surgery, the observation group had significantly lower serum T-PSA and F-PSA levels than the control group (P<0.05). At 3 months after surgery, the International Index of Erectile Function 5 (IIEF-5) scores and Chinese Index of Sexual Function for Premature Ejaculation (CIPE) scores of the observation group were significantly higher than those of the control group (P<0.05), and incidence of postoperative complications was significantly lower than the control group (P<0.05). Conclusion: HOLEP is safer in treating patients with large-volume prostate. It can improve urodynamics, reduce levels of T-PSA and F-PSA, and reduce postoperative complications.
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2021, Vol. 27 
