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| An Analysis of Influencing Factors of Early Neurological Deterioration After Revascularization in Patients with Acute Large Artery Occlusive Cerebral Infarction |
| CHEN Min, FENG Ling, TU Shuangyan, et al |
| West China Hospital, Sichuan University, Sichuan Chengdu 610041, China |
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Abstract Objective: To explore the factors affecting the early neurological deterioration(END) after vascular recanalization treatment in patients with acute aortic occlusion cerebral infarction, and to provide reference for the early identification of poor prognosis. Methods: A total of 120 patients with anterior circulation major artery occlusive cerebral infarction admitted to the Department of Neurology of our hospital from October 2017 to October 2020 were selected as the research subjects. According to whether the recanalization after treatment in patients with occurrence of END the patients were divided into the END group with 32 cases and the non-END group with 88 cases. The clinical data of two groups of patients were compared, and analysis of dangerous factors was conducted with Logistic regression. Variables of statistical significance were assigned values, and prediction model was made with R software (R3.3.2) and package RMS and verified with receiver operating characteristic curve (ROC), consistency index (C-index) and calibration diagram. Results: Logistic regression analysis showed that age ≥ 65 years, systolic blood pressure ≥ 140 mmHg, NIHSS score ≥20 points, large area of cerebral infarction and NLR ≥4.20 were independent risk factors for the occurrence of END after thrombolytic therapy in patients with cerebral infarction. The histogram model of risk prediction of END after thrombolytic therapy constructed according to the above risk factors has good differentiation and high consistency with the actual observed values. Conclusion: Age, systolic blood pressure, NIHSS score, large area of cerebral infarction and NLR before thrombolysis are independent risk factors for the occurrence of END in patients, which need to be vigilant about clinically.
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2021, Vol. 27 
