血清Activin-A联合肺部超声评分对急性呼吸窘迫综合征严重程度及预后的评估价值

doi:10.3969/j.issn.1006-6233.2021.10.023

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Abstract Objective: To explore the evaluation value of serum Activin-A (Activin-A) combined with lung ultrasound score (LUS) for the severity and prognosis of acute respiratory distress syndrome (ARDS). Methods: 160 ARDS patients admitted to the intensive care unit (ICU) of our hospital (January 2018 to December 2020) were selected. According to the severity of the disease, they were divided into severe group (n=80), moderate group (n=52), mild group (n=28); according to the 28d prognosis, they were divided into death group (n=40) and survival group (n=120), the other 60 healthy people were selected as the control group during the same period.. Detection of serum Activin-A and LUS, Pearson correlation analysis of serum Activin-A level, LUS and oxygenation index (OI) correlation, multivariate Logistics regression analysis of adverse prognostic factors of ARDS, ROC curve to determine the evaluation value of serum Activin-A combined with LUS on the poor prognosis of ARDS patients. Results: Serum Activin-A levels and LUS were significantly higher in the ARDS group than in the control group (P＜0.05). Serum Activin-A levels and LUS were significantly higher in the severe group than in the mild and moderate groups, and serum Activin-A levels and LUS were significantly higher in the moderate group than in the mild group (P＜0.05).Pearson correlation analysis showed that serum Activin-A levels and LUS were negatively correlated with OI (P<0.05). Multivariate logistic regression analysis showed that OI (OR=0.957, 95%CI: 0.932~0.981) was an independent protective factor for poor prognosis of ARDS, Activin-A (OR=1.012, 95%CI: 1.006~1.018), LUS (OR=1.328, 95%CI: 1.128~1.564) were independent risk factors (P<0.05). The ROC curve showed that the area under the curve (AUC) of Activin-A+LUS (AUC=0.922, 95%CI: 0.869~0.958) predicting poor prognosis of ARDS patients was significantly greater than that of Activin-A (AUC=0.841, 95%CI: 0.775~0.894), LUS (AUC=0.792, 95%CI: 0.721~0.852) assessment. Sensitivity, specificity, accuracy are 87.04%, 89.62%, 88.98%. Conclusion: Serum Activin-A and LUS are closely related to the severity and prognosis of ARDS, and combined detection can improve the prognostic value of ARDS.

Key words： Acute respiratory distress syndrome Prognosis Activin-A Lung ultrasound score

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	SHU Jiaojie
	ZHANG Yan
	GUO Yumei
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SHU Jiaojie,ZHANG Yan,GUO Yumei, et al. The Evaluation Value of Serum Activin-A Combined with Lung Ultrasound Score for the Severity and Prognosis of Acute Respiratory Dstress Syndrome[J]. HeBei Med, 2021, 27(10): 1692-1696.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.10.023 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I10/1692

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