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| Analysis on Influence of Sequential Chemoradiation and Concurrent Chemoradiation on the Occurrence of Radiation Pneumonia in Patients with Lung Cancer and Its Relationship with Lung Function |
| REN Lili, SONG Yiling, CHEN Yun, et al |
| People's Hospital of Fuyang City, Anhui Fuyang 236000, China |
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Abstract Objective: To investigate the clinical efficacy of sequential chemotherapy and concurrent chemotherapy for lung cancer, the incidence of radiation pneumonitis (RP), and the influence on lung function. Methods: A total of 60 lung cancer patients admitted to our hospital from October 2017 to October 2020 were selected. According to the random number table, they were simply randomly divided into sequential groups and synchronous groups, with 30 cases in each group. The sequential group was treated with sequential radiotherapy and chemotherapy, and the synchronous group was treated with concurrent radiochemotherapy. The clinical efficacy, incidence of radiation pneumonia and changes in lung function index levels were compared between the two groups. Results: The total effective rate of the synchronous group (70.00% vs 46.67%) was higher than that of the sequential group, but the difference was not statistically significant (P>0.05). The overall clinical efficacy of the synchronous group was significantly better than that of the sequential group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of radiation pneumonia between the two groups (P>0.05). The rank sum test showed that the overall situation of radiation pneumonia in the sequential group was more serious than that in the synchronous group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in lung function indexes between the two groups before treatment (all P>0.05); after treatment, FEV1[(1.69±0.18 vs 1.42±0.31)L], FVC[(3.02±0.27 vs 2.86) in the synchronous group ±0.32)L], FEV1/FVC[(56.09±4.86 vs 49.51±8.56)%] were significantly higher than the sequential group, and the difference was statistically significant (all P<0.05). Conclusion: Compared with sequential radiotherapy and chemotherapy, the overall curative effect of concurrent radiotherapy for lung cancer is better. It can reduce the degree of radiation pneumonitis and can significantly improve the level of lung function in patients.
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2021, Vol. 27 
